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Preparation method of high-content aglycon soybean isoflavone

A soybean isoflavone and aglycone type technology, applied in the direction of organic chemistry and the like, can solve the problems of small loss of soybean isoflavone aglycone, no proposed cost, high conversion rate, and achieve no toxic substances residue, easy realization, and low cost. Effect

Inactive Publication Date: 2011-08-31
天津市尖峰天然产物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although there are many reports on the enzymatic hydrolysis and acid hydrolysis preparation process of aglycon-type soybean isoflavones at home and abroad, there is still no proposal for a low-cost, high conversion rate, and low loss of soybean isoflavone aglycone that is suitable for industrial production. Process method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Disperse soybean isoflavones with a total isoflavone content of 40% in a low-alcohol aqueous solution with a volume fraction of 20% of 10 times its weight, and keep stirring under reflux at 75°C;

[0025] 2) After the temperature is stable, add 0.5% mineral acid of the solution mass, and keep stirring for 6 hours;

[0026] 3) After the reaction stops, distill out the ethanol in the solution, cool it to below 4°C, and let it stand for 8 hours;

[0027] 4) Filter the crystals, wash with water until neutral, and obtain aglycon-type soybean isoflavones with a total isoflavone content of 50%.

Embodiment 2

[0029] 1) Disperse soybean isoflavones with a total isoflavone content of 50% in a low-alcohol aqueous solution with a volume fraction of 25% of 15 times its weight, and keep stirring under reflux at 75°C;

[0030] 2) After the temperature is stable, add 1% inorganic acid of the solution mass, and keep stirring for 6 hours;

[0031] 3) After the reaction stops, distill out the ethanol in the solution, cool it to below 4°C, and let it stand for 8 hours;

[0032] 4) Filter the crystals, wash with water until neutral, and obtain aglycon-type soybean isoflavones with a total isoflavone content of 60%.

Embodiment 3

[0034] 1) Disperse soybean isoflavones with a total isoflavone content of 60% in a low-alcohol aqueous solution with a volume fraction of 30% that is 20 times its weight, and keep stirring under reflux at 80°C;

[0035] 2) After the temperature is stable, add mineral acid with a solution mass of 1.5%, and keep stirring for 6.5 hours;

[0036] 3) After the reaction stops, distill out the ethanol in the solution, cool it to below 4°C, and let it stand for 8 hours;

[0037] 4) Filter the crystals, wash with water until neutral, and obtain aglycon-type soybean isoflavones with a total isoflavone content of 60%.

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Abstract

The invention discloses a process method for preparing aglycon soybean isoflavone by performing acid hydrolysis with primary proportion soybean isoflavone as a raw material. The method comprises the following steps of: scattering the primary proportion soybean isoflavone into a low-concentration ethanol aqueous solution of which the weight is 10-30 times that of the primary proportion soybean isoflavone; keeping return flow agitation at a temperature of 70-90 DEG C; after the temperature keeps stable, adding inorganic acid in an amount of 0.2-2 percent of the mass of the solution; preserving heat and stirring for 3-10 hours; after a reaction stops, evaporating ethanol out of the solution; cooling to less than 0-10 DEG C; filtering and crystallizing; and washing with water to a neutral state so as to obtain the aglycon soybean isoflavone. The process is easy, convenient and practical, and has high transformation ratio, low cost, mechanical application of acid liquors and small environmental pollution.

Description

technical field [0001] The invention relates to a method for preparing high-content aglycon-type soybean isoflavones, in particular to a method for preparing high-content aglycon-type soybean isoflavones suitable for industrial production with low cost and without using toxic solvents such as methanol. Background technique [0002] Soybean isoflavones can inhibit the occurrence and development of atherosclerosis by improving lipid metabolism, improving vascular compliance, and exerting antioxidant effects, thereby reducing the morbidity and mortality of human cardiovascular diseases. As a big soybean producing country, my country produces a large amount of agricultural product processing waste every year. Making full use of these resources to continuously develop soybean isoflavone-related products is not only conducive to the recycling of waste, but also can bring good economic and social benefits. [0003] Soy isoflavones are natural phytoestrogens that are refined from so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/36C07D311/40
Inventor 孙华庚
Owner 天津市尖峰天然产物研究开发有限公司
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