Preparative gas-phase chromatograph device for separating and purifying high-boiling-point volatile monomer component

Abstract

The invention discloses a preparative gas-phase chromatograph device for separating and purifying a high-boiling-point volatile monomer component, comprising a column temperature tank, a shunting three-way valve, a sample collection device, a post-column heating device, a sample inlet, a vaporizing chamber, a separation system and a detection device, wherein the sample inlet, the vaporizing chamber, the separation system and the detection device are sequentially communicated, the shunting three-way valve, the vaporizing chamber and the separation system are arranged in the column temperature tank, the sample collection device and the post-column heating device are arranged outsides the column temperature tank, the inlet of the shunting three-way valve is communicated with the outlet of the separation system, one outlet of the shunting three-way valve is communicated with the sample collection device through a pipeline, and the post-column heating device comprises an insulation sleeve sleeved on a pipeline and a temperature control device used for detecting and regulating the temperature in the insulation sleeve. The temperature of the pipeline controlled by the post-column heating device is higher than that in the column temperature tank, thereby the high-boiling-point volatile monomer component is difficult to condense when transported to the sample collection device in the pipeline, mixing of components which sequentially flow out is efficiently avoided, and the purity of a preparative target object is enhanced.

Description

technical field [0001] The invention relates to a device for separating gas in the fields of chemical industry, pharmacy, environmental protection and the like, in particular to a preparative gas chromatography device. Background technique [0002] At present, preparative liquid chromatography has been widely used in the field of pharmaceutical industry, but liquid chromatography is often incapable of separating isomers in highly correlated substances and complex mixtures, while gas chromatography can be very Good separation of many organic substances, based on the above advantages, preparative gas chromatography will have a good prospect in the field of fractionation of mixtures. [0003] Preparative gas chromatography is characterized by good chromatographic separation and high reproducibility of retention time, and the separation characteristics of the sample are based on the vapor pressure, polarity and spatial structure of the analyte. Although preparative gas chromato...

AI Technical Summary

Problems solved by technology

Although fractionation by preparative gas chromatography is not a new concept, and studies have shown the potential of using preparative gas chromatography to obtain milligram-level pure compounds from complex mixtures, the current application of preparative gas chromatography is still limited.

One of the important reasons is the collection of samples after separation, especially for volatile components with high boiling points. In general, during the separation and collection process of preparative gas chromatography, the components flowing out of the column directly enter the collection device, but There is a heat loss in the connecting pipeline between the column and the collection device, which will cause a part of the high boiling point components to condense on the wall of the connecting pipeline, which will not only lead to a decrease in the yield, but also cause the former outflow component to be separated from the latter. The effluent components are mixed, which affects the purity of the target

[0004] Therefore, it is necessary to explore a preparative gas chromatographic device that overcomes the shortcomings of high-boiling volatile components that are easy to condense on the connecting pipeline, avoids the mixing of the former outflow component and the rear outflow component, and improves the purity of the target product.

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