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Piracetam orally disintegrating tablets

A technology for oral disintegrating tablets and piracetam, which is applied in the field of oral disintegrating tablets of piracetam, can solve the problems of difficulty in taking medicine, inconvenient use, inconvenient use by patients, etc., and achieves good taste, convenient taking and reasonable formula. Effect

Inactive Publication Date: 2011-07-20
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many senile dementia patients have difficulty taking medicine, so the ordinary tablet form is very inconvenient for patients who have difficulty taking medicine
Injections require medical staff to inject, and it is inconvenient for patients to use at home

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The orally disintegrating tablet of piracetam includes main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: main ingredients 25%, auxiliary materials 75%.

[0034] Piracetam 100g (25%)

[0035] Microcrystalline Cellulose 75g (18.75%)

[0036] Mannitol 120g (30%)

[0037] Lactose 78g (19.5%)

[0038] Anhydrous citric acid 2.25g (0.56%)

[0039] Cross-linked polyvinylpyrrolidone 11.25g (2.81%)

[0040] Cyclamate 4.5g (1.13%)

[0041] Menthol 3.75g (0.94%)

[0042] Micronized silica gel 3.75g(0.94%)

[0043] Magnesium stearate 1.5g (0.37%)

[0044] A total of 1000 tablets were produced

[0045] Among them, lactose and mannitol are fillers, microcrystalline cellulose and cross-linked polyvinylpyrrolidone are disintegrants, anhydrous citric acid, cyclamate and menthol are flavoring agents, magnesium stearate is lubricant, and micronized silica gel is Glidant.

[0046] The preparation ...

Embodiment 2

[0054] The orally disintegrating tablet of piracetam includes main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: main ingredients 31.25%, auxiliary materials 68.75%.

[0055] Piracetam 125g (31.25%)

[0056] Microcrystalline Cellulose 50g (12.5%)

[0057] Mannitol 150g (37.5%)

[0058] Lactose 45g (11.25%)

[0059] Anhydrous citric acid 2.25g (0.56%)

[0060] Cross-linked polyvinylpyrrolidone 15g (3.75%)

[0061] Cyclamate 3g (0.75%)

[0062] Menthol 3g (0.75%)

[0063] Micropowder silica gel 4.5g(1.13%)

[0064] Magnesium Stearate 2.25g (0.56%)

[0065] A total of 1000 tablets were produced

[0066] The preparation method of the piracetam orally disintegrating tablet of the present invention is the same as that in Example 1, and the piracetam orally disintegrating tablet with a tablet weight of 400 mg is obtained.

[0067] test results:

[0068] Tablet hardness: 32±5N

[0069] Disinte...

Embodiment 3

[0072] The orally disintegrating tablet of piracetam includes main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: main ingredients 18.75%, auxiliary materials 81.25%.

[0073] Piracetam 75g (18.75%)

[0074] Microcrystalline Cellulose 105g (26.25%)

[0075] Mannitol 100.25g (25.06%)

[0076] Lactose 84.875g (21.22%)

[0077] Anhydrous citric acid 3g (0.75%)

[0078] Cross-linked polyvinylpyrrolidone 18.75g (4.69%)

[0079] Cyclamate 3.75g (0.94%)

[0080] Menthol 0.375g (0.094%)

[0081] Micronized silica gel 6g(1.5%)

[0082] Magnesium Stearate 3g (0.75%)

[0083] A total of 1000 tablets were produced

[0084] The preparation method of the piracetam orally disintegrating tablet of the present invention is the same as in Example 1, and the piracetam orally disintegrating tablet with a tablet weight of 400 mg is obtained.

[0085] test results:

[0086] Tablet hardness: 36±5N

[0087] ...

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Abstract

The invention discloses piracetam orally disintegrating tablets and a preparation method thereof. The main drug of the piracetam orally disintegrating tablets is piracetam, and the auxiliary materials comprise microcrystalline cellulose, mannitol, lactose, crosslinked polyvinylpyrrolidone, sodium cyclamate, menthol, silica gel micropowder and magnesium stearate. The piracetam orally disintegrating tablets can effectively treat senile dementia, have convenience in taking, good taste, rapid disintegration, quick absorption and high bioavailability, and provide convenience for patients with senile dementia who have inconvenience in taking medicine.

Description

1. Technical field [0001] The invention relates to an oral pharmaceutical preparation for treating senile dementia, in particular to a piracetam orally disintegrating tablet that can disintegrate and release rapidly and has good taste. 2. Background technology [0002] Piracetam is a drug for improving brain metabolism, which is a cyclic derivative of r-aminobutyric acid. It can promote ATP in the brain, promote the synthesis of acetylcholine and enhance the conduction of nerve excitation, and has the effect of promoting metabolism in the brain. It can resist brain function damage caused by physical and chemical factors, improve retrograde health caused by hypoxia, enhance memory and improve learning ability. It is clinically used to treat senile dementia and is the first-line drug for the treatment of senile dementia. [0003] The aging trend has increased the number of patients with senile dementia, and our country will enter an aging society. At the same time, it is acco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/40A61K47/38A61P25/28
Inventor 刘均洪张媛媛王繁业吴汝林
Owner QINGDAO UNIV OF SCI & TECH
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