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Preparation method of sugarless fritillaria cirrhosa-fructus momordicae granules for relieving cough

A kind of Chuanbei Luohan, granule technology, applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., can solve the problem of high sugar content, achieve short extraction time, increased contact area , the effect of convenient dosage

Inactive Publication Date: 2011-07-13
GUANGXI JIANFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] Since the existing Chuanbeiluohan cough preparation uses sucrose as a flavoring agent, the sugar content is high, and it is not suitable for patients with diabetes, hyperglycemia, hypertension, and obesity. It is necessary to prepare a sugar-free anti-inflammatory detoxification granular products

Method used

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  • Preparation method of sugarless fritillaria cirrhosa-fructus momordicae granules for relieving cough
  • Preparation method of sugarless fritillaria cirrhosa-fructus momordicae granules for relieving cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Prescription (parts by weight):

[0057] 60 parts of Chuan Fritillaria, 25 parts of Luo Han Guo, 280 parts of loquat leaves, 440 parts of bellflower, and 0.8 parts of menthol.

[0058] Excipients: 200 parts of dextrin, 80 parts of calcium hydrogen phosphate and 0.5 part of stevia.

[0059] (2) Preparation method:

[0060] Coarsely pulverize the dried Fritillaria chinensis, and pulverize it with an airflow pulverizer for future use. After drying and coarse crushing, Luo Han Guo, loquat leaves and Platycodon grandiflorum were crushed with an airflow mill, decocted once with a semi-bionic extract 7 times the weight of the traditional Chinese medicine, at a controlled temperature of 75°C, for 0.7 hours each time, and filtered , neutralize the pH value of the extract to 7, let it stand for 12 hours, filter, and use the filtrate for later use; add 6 times the weight of ethanol solvent to boil the dregs once, control the temperature at 50°C, and take 0.8 hours, filter, a...

Embodiment 2

[0062] (1) Prescription (parts by weight):

[0063] 55 parts of Chuan Fritillaria, 20 parts of Luo Han Guo, 350 parts of loquat leaves, 180 parts of bellflower, and 0.8 parts of menthol.

[0064] Excipients: 120 parts of carboxymethyl starch, 120 parts of dextrin, 100 parts of calcium hydrogen phosphate, 0.4 parts of stevioside and 0.4 parts of xylitol.

[0065] (2) Preparation method:

[0066] The crude drug Fritillaria sichuanensis is firstly dried, coarsely pulverized, and pulverized by an airflow pulverizer for subsequent use. Luo Han Guo, loquat leaves and platycodon grandiflorum are screened, dried, coarsely crushed, crushed with an airflow mill, and mixed with acetic acid and water to form a semi-bionic extract with a pH value of 4. 4.5 times the weight of the traditional Chinese medicine. The temperature is 60°C, each time is 0.6 hours, the extracts are combined and filtered, and the pH value of the extract is neutralized to 7, let stand for 10 hours, filtered, dehyd...

Embodiment 3

[0068] (1) Prescription (parts by weight):

[0069] 40 parts of Chuan Fritillaria, 25 parts of Luo Han Guo, 400 parts of loquat leaves, 120 parts of bellflower and 1 part of menthol.

[0070] Excipients: 100 parts of starch, 120 parts of dextrin, 100 parts of calcium dihydrogen phosphate, 0.3 parts of protein sugar and 0.5 parts of high fructose.

[0071] (2) Preparation method:

[0072] The crude drug Fritillaria sichuanensis is dried, coarsely pulverized, and pulverized by an airflow pulverizer for subsequent use. Luo Han Guo, loquat leaves and platycodon grandiflorum are screened, dried, coarsely crushed, crushed with an airflow mill, decocted with 3,000 parts of ethanol containing 60% alcohol weight, controlled at a temperature of 50°C, for 0.5 hours, filtered, and removed dregs Get the alcohol extraction extract for later use. Add 3000 parts of water to decoct the dregs of the medicine, control the temperature at 95° C. for 1 hour, filter, remove the dregs of the medic...

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Abstract

The invention provides a preparation method of sugarless fritillaria cirrhosa-fructus momordicae granules for relieving cough, which comprises the following steps of: firstly, drying and coarsely crushing traditional Chinese medicines, crushing fritillaria cirrhosa through gas flow, and extracting fructus momordicae, loquat leaves and balloon flower by a semi-bionic extraction method and an ethanol extraction method or a semi-bionic extraction method or an ethanol extraction method and a water extraction method to prepare clear cream; and then, adding fritillaria cirrhosa powder, menthol and auxiliary materials to prepare granules for relieving cough by a conventional method. The granules prepared by the invention solve the problem that the granular traditional Chinese medicine preparation takes sucrose as a flavoring agent which can decompose some medical effective components and can influence absorption, and the granules can meet the requirements of all people for taking the traditional Chinese medicine preparation. The granules are especially suitable for being taken by patients with diabetes, hyperglycemia, hypertension, obesity and the like. By using the method, after the traditional Chinese medicines are coarsely crushed, the contact area between the traditional Chinese medicine powder and a solvent is increased in the extraction process, the extraction time is shortened, the transfer rate is high, the time is saved, the production cycle is shortened, the utilization ratio of the raw materials is improved, and the effective components of the raw medicines are kept.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a preparation method of sugar-free Chuanbeiluohanzhike granules. Background technique: [0002] At present, there are existing cough medicines, and most of them adopt traditional Chinese medicine and western medicine. Western medicines belong to chemical drugs, mainly antipyretic, antitussive, and anti-inflammatory drugs are used to treat cough. The stability of the curative effect is relatively poor, the side effects are large, and long-term use is relatively harmful to the human body. It belongs to the superficial treatment method, which cannot achieve the balance of yin and yang in the body and the effect of radical cure. Adopt traditional Chinese medicine prescription treatment, have better curative effect. However, the dosage of traditional Chinese medicine prescriptions is large, and it needs to be decocted and heated, and the decoction of...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61K9/16A61K47/42A61K47/36A61K47/26A61K47/16A61K47/10A61K47/02A61P11/14
Inventor 黄大权
Owner GUANGXI JIANFENG PHARMA
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