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Quality control method for extract concentrated liquor of condensed pills of six ingredients with rehmannia root

A technology of Liuwei Dihuang Pill and Paeonol is applied in the field of quality control of traditional Chinese medicines, and can solve the problems that have not been seen yet, and achieve the effects of simple operation, rapid analysis, and high-efficiency analysis method.

Active Publication Date: 2012-07-04
JIANGXI HUIREN PHARMA CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no research report on the determination of physical and chemical indicators with the goal of production process control

Method used

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  • Quality control method for extract concentrated liquor of condensed pills of six ingredients with rehmannia root
  • Quality control method for extract concentrated liquor of condensed pills of six ingredients with rehmannia root
  • Quality control method for extract concentrated liquor of condensed pills of six ingredients with rehmannia root

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Embodiment 1

[0032] Instruments and reagents

[0033] Instruments AOTF portable Luminar 5030-731 near-infrared spectrometer (BRIMROSE, USA), supporting SNAP spectrum acquisition software and CAMO chemometrics software; Aglient1100 chromatograph (Agilent, USA), DAD diode array detector; Anton Paar portable specific gravity DMA35 (Austria Anton Paar Company); multifunctional extraction tank (Changshu Pharmaceutical and Chemical Equipment General Factory), vacuum decompression concentration tank (Changshu Pharmaceutical and Chemical Equipment General Factory).

[0034] Test drugs Cortex Moutan, Cornus officinalis, Rehmannia glutinosa, Poria cocos, Alisma (Jiangxi Huiren Pharmaceutical Co., Ltd.); paeonol reference substance, loganin reference substance (China Institute for the Control of Pharmaceutical and Biological Products); methanol 1. Acetonitrile is chromatographically pure reagent, tetrahydrofuran and phosphoric acid are analytically pure, and water is ultrapure water.

[0035] Method...

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Abstract

The invention provides a quality control method for extract concentrated liquor of condensed pills of six ingredients with rehmannia root, which comprises the following steps of: 1, measuring the specific gravity, paeonol content and loganin content of the extract concentrated liquor of the qualified condensed pills of six ingredients with rehmannia root, and collecting a near infrared spectrum; 2, establishing corresponding models between the near infrared spectrum and the specific gravity, the paeonol concentration and the loganin concentration in the extract concentrated liquor of the condensed pills of six ingredients with rehmannia root respectively by adopting chemometric software; 3, measuring the near infrared spectrum of an extract concentrated liquor sample, which is to be measured, of the condensed pills of six ingredients with rehmannia root; and 4, by utilizing the corresponding models, acquiring the specific gravity, the paeonol concentration and the loganin concentration of the extract concentrated liquor sample, which is to be measured, of the condensed pills of six ingredients with rehmannia root by the chemometric software respectively.

Description

technical field [0001] The invention relates to the quality control of traditional Chinese medicines, in particular to a method for rapidly measuring the specific gravity of the concentrated liquid extracted from concentrated pills of Liuwei Dihuang Pills and the contents of loganin and paeonol. technical background [0002] Traditional Chinese medicine is one of the most original and independent intellectual property industries in China. Chinese patent medicines and decoction pieces are the main forms of clinical application of traditional Chinese medicine. Due to the complexity of the material basis of the curative effect of traditional Chinese medicine, the technical means of quality control of Chinese patent medicine are relatively extensive, which is reflected in the quality control of Chinese patent medicine adopts the control of process method, plus the quantitative detection of representative chemical index components and the qualitative inspection of preparations ....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/35A61K36/884A61P13/12A61P9/12A61P3/10A61P25/00A61K36/8945A61K9/20G01N21/359
Inventor 胡浩武耿炤王木兰杜育华梅玲华孙晓波
Owner JIANGXI HUIREN PHARMA CO LTD
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