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Preparation technology of new formulation of integrative six gentlemen decoction and production method thereof

A technology of Liujunzi decoction and its production method, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., to achieve the effect of wide target distribution

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no identical or similar literature reports at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0044]The composition of the raw materials used to make the active ingredients is——

[0045] 15 parts of ginseng, 12 parts of Atractylodes macrocephala, 12 parts of pinellia, 9 parts of poria cocos, 9 parts of tangerine peel, and 6 parts of licorice.

[0046] Its manufacturing process is as follows:

[0047] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, acc...

Embodiment 2

[0049] Prepare the following raw materials according to the aforementioned method: water decoction concentrate, nano liposome, nanoemulsion, microemulsion, nano suspension.

[0050] The composition of the raw materials used to make the active ingredients is——

[0051] 15 parts of ginseng, 12 parts of Atractylodes macrocephala, 12 parts of pinellia, 9 parts of poria cocos, 9 parts of tangerine peel, and 6 parts of licorice.

[0052] Its manufacturing process is as follows:

[0053] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, past...

Embodiment 3

[0055] Prepare the following raw materials according to the aforementioned method: extract, solid lipid nanoparticles, and nanoemulsion.

[0056] The composition of the raw materials used to make the active ingredients is——

[0057] 15 parts of ginseng, 12 parts of Atractylodes macrocephala, 12 parts of pinellia, 9 parts of poria cocos, 9 parts of tangerine peel, and 6 parts of licorice.

[0058] Its manufacturing process is as follows:

[0059] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 sq...

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Abstract

The invention relates to the preparation technology of a new formulation of integrative six gentlemen decoction and a preparation method thereof. The six gentlemen decoction comprises the following raw materials in part by weight: 15 parts of ginseng, 12 parts of largehead atractylodes rhizome, 12 parts of pinellia tuber, 9 parts of Indian buead, 9 parts of tangerine peel and 6 parts of liquoric root. The production process comprises the following steps of: alcohol / water extracting, ultrasonic crushing extracting, microwave extracting, decocting and concentrating, spray drying, high-pressure homogenizing, nanometer grinding, nanometer particle preparation and the like. The preparation technology and the production method have the advantages of multi-synergetic effect, multi-targeting effect and the like of nanometer traditional Chinese medicines. By the large-scale industrial production, the production cost can be reduced substantially, the quality of products can be improved, and the targeting and slow controlled release properties of medicaments are high; and a prepared membrane agent also can be applied to the skin of human bodies for treatment by transdermal absorption.

Description

technical field [0001] The invention relates to the preparation technology of the new dosage form of the integrated Liujunzi Decoction, and also relates to the preparation technology of the new dosage form of the integrated Liujunzi Decoction and its production method. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. [0003] Traditional Chinese medicine compound prescription embodies the holistic view, system theory, and syndrome differentiation and treatment principles of traditional Chinese medicine treatment, which emphasizes strengthening the body and eliminating pathogenic factors, and treating both symptoms and root causes. What a single ingredient can sum up. The efficacy of the compound medicine is not only related to the active substances or groups of effective substances, but also related to the auxiliary components. When the traditional Chines...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61K9/00A61P1/04A61P37/02
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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