Oral administration medicament for treating depression

A technology of depression and medicine, applied in the field of plant materials, can solve the problems of ineffectiveness, seriousness, and many side effects

Inactive Publication Date: 2012-01-11
王静怡
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The disadvantages of Western medicine are: the curative effect on various physical discomfort symptoms is not obvious, which makes the patient's compliance poor; the side effects are many and serious, which makes it difficult for patients to accept; in addition, the price of new drugs is relatively expensive, which makes it difficult for patients to bear
Patients with clinical depression are often accompanied by anxiety symptoms, and there are few research results on the anti-anxiety effect of traditional Chinese medicine for the treatment of depression

Method used

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  • Oral administration medicament for treating depression
  • Oral administration medicament for treating depression
  • Oral administration medicament for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Taking the production of 1000 pharmaceutical capsule products of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0040] Red Ginseng 666g

[0041] Astragalus 2667g

[0042] Schisandra 1333g

[0043] Hypericum perforatum 2667g

[0044] Add dextrin to 300g.

[0045] Its preparation method is as follows:

[0046] The red ginseng, 1 / 3 astragalus, and 1 / 3 schisandra in the proportioning of the present invention are crushed into 200-mesh fine powder, the rest of the medicine is decocted and extracted, concentrated to a thick paste with a relative density of 1.2, and the red ginseng and astragalus are added , schisandra powder and dextrin are mixed evenly, granulated, dried, and filled with 1000 capsules. Each capsule weighs 0.3g, and each capsule contains 7.33g of crude drug.

[0047] Taking the production of 1000 tablets of the pharmaceutical tablet product of the present invention...

Embodiment 2

[0071] Taking the production of 1000 pharmaceutical capsule products of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0072] Red Ginseng 431g

[0073] Astragalus 2157g

[0074] Schisandra 1294g

[0075] Hypericum perforatum 3451g

[0076] Add dextrin to 300g.

[0077] Its preparation process is identical with the preparation process of embodiment 1 capsule. Each capsule weighs 0.3g, and each capsule contains 7.33g of crude drug. Taking the production of 1000 tablets of the pharmaceutical tablet product of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0078] Red Ginseng 324g

[0079] Astragalus 1618g

[0080] Schisandra 971g

[0081] Hypericum perforatum 2587g

[0082] Add starch to 300g.

[0083] Its preparation process is carried out according to the preparation process of the tablet o...

Embodiment 3

[0101] Taking the production of 1000 pharmaceutical capsule products of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0102] Red Ginseng 733g

[0103] Astragalus 2933g

[0104] Schisandra 1467g

[0105] Hypericum perforatum 2200g

[0106] Add dextrin to 300g.

[0107] Its preparation process is identical with the preparation process of embodiment 1 capsule. Each capsule weighs 0.3g, and each capsule contains 7.33g of crude drug. Taking the production of 1000 tablets of the pharmaceutical tablet product of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0108] Red Ginseng 550g

[0109] Astragalus 2200g

[0110] Schisandra 1100g

[0111] Hypericum perforatum 1650g

[0112] Add starch to 300g.

[0113] Its preparation process is carried out according to the preparation process of the tablet ...

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Abstract

The invention relates to an oral administration medicament for treating depression, which is prepared from the following Chinese medicinal raw materials in part by mass: 1 to 5 parts of red ginseng, 5 to 20 parts of astragalus, 3 to 10 parts of Chinese magnoliavine fruit and 8 to 15 parts of hypericum perforatum L by the conventional preparation method. The oral administration medicament can be capsules or tablets or granules or oral liquid in pharmaceutics. Medicinal effect experiments prove that the medicament can improve the appetite, interest, memory acquisition and memory retention capability, activity and exploration capability of chronic depressed model rats obviously, can improve the content of 5-HT and NE in brains of the chronic depressed model rats obviously, and promote that an action mechanism of depression resistance of the medicament is possibly associated with the inhibition of reuptake on 5-HT and NE, and the effect of the medicament is equivalent to that of fluoxetine hydrochloride. The medicament has a certain effect of anxiety resistance, and the effect is similar to that of diazepam. Pharmacological experiments and clinical observation prove that the medicament has high anti-depression effect and a certain effect of anxiety resistance.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] Depression is a common mental illness, mainly manifested as low mood, loss of interest, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, worry that you have various diseases, and feeling that you are suffering from various diseases in your body. Discomfort, and in severe cases, suicidal thoughts and behaviors may appear. Depression is mainly based on depressed mood, slow thinking and decreased willpower, and there are various somatic symptoms in most cases. These include sleep disturbances (difficulty falling asleep, light sleep, waking up early, or feeling sleepy when others thought he was sleeping well), fatigue or loss of energy, decreased appetite (70% of people with depression experienc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57A61P25/24
Inventor 王静怡
Owner 王静怡
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