Preparation method and quality control method of arbidol hydrochloride tablet

Abstract

The invention relates to a preparation method and a quality control method of an arbidol hydrochloride tablet. The arbidol hydrochloride tablet comprises the following major ingredients: arbidol hydrochloride, microcrystalline celluloses, milk sugar, starch, low-substituted hydroxypropyl celluloses, talcum powder, magnesium stearate and a right amount of adhesive starch slurry. The preparation method of the arbidol hydrochloride tablet comprises the following steps of: preprocessing; preparing granules; and tabletting. The quality control method of the arbidol hydrochloride tablet comprises the following steps of: measuring dissolution rate, related substances and content. For overcoming the defects of the traditional variety, the invention provides the preparation method of the arbidol hydrochloride tablet, which has the advantages of broad spectrum, high efficiency, stable quality, simple process, low cost, easy patient acceptance, and the quality control method of the arbidol hydrochloride tablet, which has the advantages of convenience, fastness, accurate quantification, good specificity and high applicability.

Description

technical field [0001] The invention relates to the field of antiviral western medicine manufacture, in particular to a preparation method of Arbidol hydrochloride tablets and a quality control method thereof. Background technique [0002] The antigenic variability of influenza virus and the multi-resistance of acute respiratory viral infection prevent people from obtaining a vaccine that is safe enough to treat and prevent such diseases. For the above reasons, the application of gamma-interferon is somewhat uncertain. In this field, the chemical treatment of influenza and acute respiratory viral infections played an important role at that time. In modern practice, adamantane derivatives such as amantadine have been widely used as antiviral substances, however, their narrow activity spectrum (acting only on influenza virus A), considerable side effects and easy to develop tolerance etc. Reduced their clinical application value. In the extensive search for antiviral drugs ...

AI Technical Summary

Problems solved by technology

[0004] At present, Arbidol hydrochloride capsules and granules have been marketed in China. Their products have the disadvantages of strict storage conditions, easy moisture absorption and deterioration, high production costs, and low patient acceptance rate.

At the same time, although there are literature reports on its quality control methods at home and abroad, there are disadvantages such as cumbersome operation and high requirements for instruments and equipment.

Images