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Preparation with function of reducing blood sugar and preparation method thereof

A hypoglycemic and preparation technology, applied in the field of preparation and preparation of hypoglycemic drugs, to achieve the effects of stable process, high purity and good water solubility

Inactive Publication Date: 2011-06-08
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of Japanese hairy lettuce for lowering blood sugar

Method used

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  • Preparation with function of reducing blood sugar and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Wash 5,000 grams of Japanese hairy lettuce, dry it, cut it into small pieces, add 75-100L of distilled water to soak, make the medicinal materials completely submerged in water, heat and reflux to extract 2-3 times, each time for 2-3h, the extract is used for 4 Filter with a layer of gauze, collect the filtrate, combine the filtrate, centrifuge, take the supernatant, concentrate under reduced pressure to obtain a thick paste A 1 (The specific gravity measured at 80-85°C is 1.20-1.34) More than 1000 grams, which contains more than 250 grams of polysaccharides and more than 75 grams of flavonoids; wash 200 grams of Japanese hairy lettuce, dry it, cut it into small pieces, crush it, and pass through 60 mesh Sieve to get powder B 1 140-170 grams, thick paste A 1 1000g with Japanese Asparagus Raw Herbal Powder B 1 Mix 80-110 grams thoroughly, dry in a vacuum oven below 60°C, and pulverize to obtain mixed powder C of raw medicinal materials and medicinal material extract...

Embodiment 2

[0043] Wash 2000 grams of Japanese hairy lettuce, dry it, cut it into small pieces, soak it in 30-40L of distilled water, make the medicinal materials completely submerged in water, and ultrasonically extract it at 50-80°C for 2-3 times, each time 2-3h, filter the extract with 4 layers of gauze, collect the filtrate, combine the filtrate, centrifuge, take the supernatant, concentrate under reduced pressure to a thick paste A 2 (The specific gravity measured at 80-85°C is 1.20-1.34) more than 360 grams, which contains more than 100 grams of polysaccharides and more than 30 grams of flavonoids; wash 100 grams of Japanese hairy vegetables, dry them, cut them into small pieces, crush them, and pass through 60 meshes Sieve to get powder B 2 75-85 grams, thick paste A 2 350g with Japanese Asparagus Raw Herb Powder B 2 Mix 30-40 grams thoroughly, dry in a vacuum oven below 60°C, and pulverize to obtain mixed powder C of raw medicinal materials and medicinal material extracts 2 ...

Embodiment 3

[0045] Wash 2000 grams of Japanese hairy lettuce, dry it, cut it into small pieces, soak it in 30-4-L distilled water, make the medicinal materials completely submerged in water, soak and extract at 60-80°C for 2-3 times , 2-3 hours each time, filter the extract with 4 layers of gauze, collect the filtrate, combine the filtrate, centrifuge, take the supernatant, concentrate under reduced pressure to a thick paste A 3 (The specific gravity measured at 80-85°C is 1.20-1.34) More than 400 grams, including more than 100 grams of polysaccharides and more than 30 grams of flavonoids; wash 80 grams of Japanese hairy lettuce, dry, cut into small pieces, crush, and pass through 60 meshes Sieve to get powder B 3 60-70 grams, thick paste A 3 400g with Japanese Asparagus Raw Herb Powder B 3 Mix 35-45 grams thoroughly, dry in a vacuum oven below 60°C, and pulverize to obtain mixed powder C of raw medicinal materials and medicinal material extracts 3 ;Using wet granulation, first mix ...

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Abstract

The invention discloses a preparation with a function of reducing blood sugar, which is prepared from the aqueous extract of picris japonica. The preparation method of the preparation with the function of reducing blood sugar comprises the following steps: cleaning and airing the picris japonica, cutting the picris japonica into small pieces, adding distilled water for soaking, extracting for 2-3times (2-3 hours every time), filtering the extracting solutions, collecting the filtered solutions, merging the filtered solutions, centrifuging, taking the supernatant solution, and concentrating under the reduced pressure to obtain thick paste A; cleaning and airing the picris japonica, cutting the picris japonica into small pieces, crushing, and sieving with a 60-mesh sieve to obtain powder B; fully and evenly mixing the thick paste A of the aqueous extract of the picris japonica and a proper amount of the raw medicinal powder B of the picris japonica, wherein the quality mixing ratio of A to B is (8.5:1)-(13.5:1); drying at the temperature lower than 60 DEG C, and crushing to obtain mixed powder C of raw medicines and medicine extracts; and then, preparing the preparation. In the invention, the effective parts of the aqueous extract of the picris japonica are prepared into the pharmaceutical preparation with the function of reducing blood sugar, and the process is stable, simple and feasible.

Description

technical field [0001] The invention relates to a preparation with hypoglycemic effect and a preparation method thereof, in particular to a preparation of a hypoglycemic drug made from Japanese spinach and a preparation method thereof. Background technique [0002] Plants of the genus Trichosanthes include Japanese Trichosanthes, Trichosanthes (formerly subspecies Trichosanthes, single Trichosanthes), Yunnan bitter cabbage, Xinjiang Trichosanthes, annual, biennial, and perennial branched herbs. [0003] Japanese Maolian ( Picris japoncia Thunb) is a composite plant, also known as: gun knife dish. In my country, it is mainly distributed in Hebei, Shanxi, Shaanxi, Jilin, Heilongjiang and other places, among which Shanxi is mainly distributed in Taiyuan and surrounding counties and cities, Jiaocheng, Wutai and other areas. Born in hillside grasslands, bushes, fields and rivers, 650-3650 meters above sea level. Japan and Russia are also distributed. The whole herb is used i...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P3/10
Inventor 高建平张志勇段拴贵刘先
Owner SHANXI MEDICAL UNIV
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