Preparation method of medicine grade lysine acetate

A technology of lysine acetate and lysine, which is applied in the preparation of organic compounds, chemical instruments and methods, and cyanide reaction preparation, can solve the problems of high cost, limited application, and cumbersome steps, and achieve simplified operation and shortened production time. Technological process, the effect of realizing value

Active Publication Date: 2011-05-25
BENGBU BBCA MEDICINE SCI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the methods for preparing pharmaceutical grade lysine acetate that meet the standards of the Pharmacopoeia are refined from food grade lysine acetate. The cost is high and the steps are cumbersome, which limits its application in pharmaceuticals.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] L-lysine was fermented according to the method disclosed in the research on L-lysine fermentation reported by Zhang Weiguo (Fermentation Technology Communication, 2005, 34 (1)). Add 70L of lysine fermentation broth (containing 30% L-lysine) into a 100L reactor, heat up to 55°C with stirring, start to slowly add glacial acetic acid dropwise, adjust the pH of the reaction solution to 6.0, and stop the dropwise addition . Heat the reaction for 5 hours, add 1.0 kg of activated carbon, heat and decolorize for 1 hour, and filter while it is hot to obtain a clear solution. Press back into the reaction kettle, use 0.8 kg of activated carbon, keep warm for 1 hour for decolorization, and then decolorize again, so that the light transmittance of the reaction solution is 96.0%. Concentrate in vacuum at 75°C to a density of 1.26-1.30g / cm 3 When the temperature was lowered to 55°C at a rate of 5°C / h, fine white crystals were formed. After 3 hours of slow stirring at the temperature...

Embodiment 2

[0026] L-lysine was fermented according to the method disclosed in the research on L-lysine fermentation reported by Zhang Weiguo (Fermentation Technology Communication, 2005, 34 (1)). Add 70L of lysine fermentation broth (containing 30% L-lysine) into a 100L reactor, heat up to 55°C with stirring, start to slowly add glacial acetic acid, adjust the pH of the reaction solution to 5.5, and stop the dropwise addition . Heat the reaction for 5 hours, add 1.0 kg of activated carbon, heat and decolorize for 2 hours, and filter while it is hot to obtain a clear liquid. The light transmittance of the reaction solution was measured to be 95.5%. Concentrate in vacuum at 75°C to a density of 1.26-1.30g / cm 3 When the temperature was lowered to 55°C at a rate of 5°C / h, fine white crystals were formed. After 3 hours of slow stirring at the temperature, the temperature was lowered to 35°C at a rate of 2°C / h to precipitate a large amount of white crystals. Discharging, throwing filter. T...

Embodiment 3

[0030] L-lysine was fermented according to the method disclosed in the research on L-lysine fermentation reported by Zhang Weiguo (Fermentation Technology Communication, 2005, 34 (1)). Add 70L of lysine fermentation broth (containing 30% L-lysine) into a 100L reactor, heat up to 55°C with stirring, start to slowly add glacial acetic acid, adjust the pH of the reaction solution to 6.5, and stop the dripping . Heat the reaction for 5 hours, add 1.0 kg of activated carbon, heat and decolorize for 2 hours, and filter while it is hot to obtain a clear liquid. Press back into the reaction kettle for secondary decolorization, and the light transmittance of the reaction solution is 96.5%. Concentrate in vacuum at 75°C to a density of 1.26-1.30g / cm 3 When the temperature was lowered to 55°C at a rate of 5°C / h, fine white crystals were formed. After 3 hours of slow stirring at the temperature, the temperature was lowered to 35°C at a rate of 2°C / h to precipitate a large amount of whit...

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PUM

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Abstract

The invention provides a preparation method of medicine grade lysine acetate, which comprises the following steps: 1) enabling a biological fermentation broth containing L-lysine to be reacted with acetic acid, adding activated carbon into reaction solution for performing decolorization at least once, then concentrating, crystallizing and getting a lysine acetate crude product; and 2) adding the lysine acetate crude product obtained in the step 1) into distilled water for dissolution, performing the decolorization at least once, and further performing fine filtration, concentration and crystallization. Various indicators of the medicine grade lysine acetate prepared according to the invention are in line with the pharmacopoeia standard, the preparation of the medicine grade lysine acetate by using the lysine fermentation broth has no harsh reaction conditions and is applicable to industrial production, and the preparation of the medicine grade lysine acetate by using the lysine fermentation broth which is relatively low in price can realize value appreciation to the maximum extent.

Description

technical field [0001] The invention relates to a preparation method of pharmaceutical grade lysine acetate. Background technique [0002] Lysine acetate is one of the essential amino acids for the human body. It has the nutritional effect of supplementing protein and can be used in medicine to prepare amino acid injections and oral preparations. It is used for the preparation of amino acid injection and oral preparations; as an auxiliary drug for diuretics to treat lead poisoning caused by the reduction of chloride in the blood; it can form salts with acidic drugs to reduce adverse reactions. [0003] Currently, food-grade lysine acetate is mainly supplied on the market for nutritional purposes. Food-grade lysine acetate contains trace miscellaneous sugars, excessive metal content, and yellowish color. However, the methods for preparing pharmaceutical-grade lysine acetate that meet the standards of the Pharmacopoeia are mostly refined from food-grade lysine acetate. The c...

Claims

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Application Information

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IPC IPC(8): C07C229/26C07C227/40
Inventor 韦亚锋陈文婕张亚江立新赵辉
Owner BENGBU BBCA MEDICINE SCI DEV
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