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Venous retention needle suite with hirudin anticoagulation tube sealing device

A technology of intravenous indwelling needles and hirudin, which is applied in the field of medical devices, can solve the problems of cumbersome extraction steps of natural hirudin, limitations in research and clinical application, and difficulty in obtaining a sufficient amount of pure products, so as to reduce the risk of phlebitis and reduce the risk of medical treatment. The effects of preventing disputes and reducing the workload of nurses

Inactive Publication Date: 2011-05-25
天津百新生物技术研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the cumbersome extraction steps of natural hirudin, the difficulty of raising leeches, and the lack of sources of leeches, it is difficult to obtain a sufficient amount of pure products, which limits research and clinical applications.

Method used

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  • Venous retention needle suite with hirudin anticoagulation tube sealing device
  • Venous retention needle suite with hirudin anticoagulation tube sealing device
  • Venous retention needle suite with hirudin anticoagulation tube sealing device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] figure 1 It is a schematic structural diagram of the venous indwelling needle kit with hirudin anticoagulant tube sealing device of the present invention. Such as figure 1 As shown, the venous indwelling needle kit with hirudin anticoagulant tube sealing device of the present invention includes a cannula 1 guided by a puncture needle 17 into the vein, and a transparent built-in isolation sealing plug 3 connected to the rear end of the cannula 1 The tee 2 and the infusion connector 6 used to connect the infusion line or the blood collection tube line.

[0046] One end of the transparent tee 2 is connected to the sleeve 1, one end is sealed by the isolation sealing plug 3, and the third end is connected to the infusion connector 6 through the extension tube 4. The cannula 1 is sleeved outside the puncture needle 17, and the tip of the puncture needle 17 protrudes from the front end of the cannula 1. The rear end of the puncture needle 17 is provided with a puncture needle...

Embodiment 2

[0053] Comparative experiment

[0054] The concentration of hirudin is 0.01mg / ml~50mg / ml, and each use is about 1ml-15ml according to different needs.

[0055]

[0056]

[0057] The relationship between hirudin and clotting factors is as follows:

[0058] First, recombinant hirudin and α-thrombin are equimolar non-covalently combined to form a stable complex (its dissociation constant is very small, 0.8×10 -10 mol or 2.0×10 -14 mol). At this time, all the protease hydrolysis functions of thrombin are blocked, so hirudin can not only prevent the coagulation of fibrinogen, but also block the hemostatic reaction catalyzed by thrombin, such as the activation of factors V, VIII and Ⅲ and the platelets induced by thrombin The reaction prevents the generation of thrombin caused by the feedback of prothrombin activation. At the same time, hirudin does not interfere with the biosynthesis of coagulation factors and has no effect on antithrombin III (AT-III).

[0059] Second, when hirudin, disu...

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Abstract

The invention provides a venous retention needle suite with a hirudin anticoagulation tube sealing device, which comprises a casing, a transparent tee joint and a transfusion joint, wherein the casing is guided by a puncture needle and inserted into a vein; the transparent tee joint is connected to a built-in isolated sealing plug at the rear end of the casing; the transfusion joint is connected with a transfusion tube or a blood taking tube; the transparent tee joint is connected with the transfusion joint by an extension tube; the transfusion joint is sealed by a sealed end cap; one end of the transparent tee joint connected with the extension tube forms a double-cavity joint; one end of the double-cavity joint is connected with the extension tube, and the other end of the double-cavity joint is connected with a tube sealing device; and the tube sealing device comprises a liquid storing bag in a support and a roller which is arranged between the two side walls of the support and used for pushing the liquid in the liquid storing bag forwards. The venous retention needle suite with the hirudin anticoagulation tube sealing device can ensure that a tubular cavity of the retention needle is filled with the tube sealing liquid. The tube sealing liquid in the tube sealing device is hirudin diluent which has good anticoagulation effect and does not influence any index of serum test in blood.

Description

Technical field [0001] The invention belongs to the technical field of medical devices, and particularly relates to a venous indwelling needle kit with a hirudin anticoagulation tube sealing device. Background technique [0002] In recent years, with the rapid development of medical science, intravenous indwelling needles that can relieve the pain of repeated puncture of patients have been widely used in the rescue of critically ill patients, intravenous hypernutrition and intermittent intravenous antibiotics or other drugs. The intravenous indwelling needle includes a puncture needle and a cannula. After the puncture needle is inserted into the patient's vein with the cannula, the puncture needle is pulled out, the cannula is left in the body, and the outer end is connected to an infusion device or a blood sampling device. The intravenous indwelling needle can be used not only for routine intravenous infusion, but also for intermittently multiple blood sampling, which not only ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/158A61B5/153A61L31/04A61L31/02A61L31/06
Inventor 刘晨刘金雪
Owner 天津百新生物技术研发有限公司
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