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Collagen sponge and preparation method thereof

A collagen sponge and collagen technology, applied in bandages, absorbent pads, medical science, etc., can solve the problems that glutaraldehyde cannot be completely removed and affects the histocompatibility of products, so as to avoid the residual toxicity of chemical reagents and achieve good growth conditions , the effect of promoting cell proliferation

Inactive Publication Date: 2011-05-25
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there is a washing process, unreacted glutaraldehyde cannot be completely removed, which will inevitably affect the histocompatibility of the product

Method used

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  • Collagen sponge and preparation method thereof
  • Collagen sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Mix 5g of hydrous collagen (about 98% of water content) with 5g of water, and stir evenly with a defoaming mixer to obtain an aqueous solution with a solid content of 1%. Put the aqueous solution into the test tube, remove air bubbles, and irradiate 25kGy with cobalt-60 gamma rays after sealing to obtain collagen hydrogel. This collagen hydrogel was freeze-dried at -60°C to obtain a collagen sponge.

Embodiment 2

[0040] Put water-containing collagen (about 98% water) into the test tube, remove air bubbles, seal it and place it at a wavelength of 254nm and a power of 1.66mW / cm 2 Under the ultraviolet device, the working distance is 5 cm, irradiated for 4 hours, and the collagen hydrogel is obtained. This collagen hydrogel was freeze-dried at -20°C to obtain a collagen sponge.

Embodiment 3

[0042] Mix 1 gram of hydrous collagen (water content about 98%) with 9 g of water, and stir evenly with a defoaming mixer to obtain an aqueous solution with a solid content of 0.2%. Put the aqueous solution into the test tube, remove air bubbles, seal the tube and irradiate 125kGy with electron beam to obtain collagen hydrogel. This collagen hydrogel was freeze-dried at -60°C to obtain a collagen sponge.

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Abstract

The invention discloses collagen sponge and a preparation method thereof. The collagen sponge does not contain a chemical cross-linking agent, has the porosity of over 90 percent, and is prepared by performing radiation cross-linking on aqueous solution of collagen and then freeze-drying the aqueous solution of collagen; and sterilization is performed during cross-linking so that the biosafety problem caused during preparation is solved. The collagen sponge prepared by the method has no residue of chemical reagents, better biocompatibility and structural uniformity, and adjustable degradation rate and mechanical strength, and can be used as biomedical materials such as dressing, tissue engineering stents, artificial tissue components, tissue fillers, embolic agents and the like.

Description

technical field [0001] The invention relates to the preparation of biological materials, in particular to a collagen sponge and a preparation method thereof. The collagen sponge is suitable for but not limited to the field of biomedical materials. Background technique [0002] Collagen is the most widely distributed, most abundant and diverse fibrous protein family in animals. Collagen present in various organs and tissues accounts for more than 30% of the total protein in the human body. As the main component of the extracellular matrix, collagen is regarded as the most useful biomaterial. Collagen has low antigenicity, biodegradability, easy absorption, non-toxicity, good biocompatibility, and has hemostatic effect, playing an important role in tissue repair. [0003] It is known that the use of collagen sponge for artificial skin transplantation in wounds can promote cell proliferation and accelerate tissue healing by virtue of its porous structure suitable for cell grow...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/44
Inventor 许零张向梅
Owner PEKING UNIV
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