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Biological functionalized nano titanium material and preparation method thereof

A biofunctionalized, nano-titanium technology, applied in the field of biomedical materials, can solve the problems of inability to combine with surrounding tissues of the human body, low success rate of titanium implant implantation, poor initial stability, etc., to improve proliferation and differentiation ability, good application Promising, low-cost effects

Inactive Publication Date: 2011-05-18
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the biological inertness of titanium and titanium alloys, poor osseointegration, they cannot be well integrated with the surrounding tissues of the human body, and there are disadvantages such as long healing time and poor initial stability, resulting in a low success rate of titanium implant implantation

Method used

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  • Biological functionalized nano titanium material and preparation method thereof
  • Biological functionalized nano titanium material and preparation method thereof
  • Biological functionalized nano titanium material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, biofunctionalized nano-titanium material (TiO 2 Preparation of nanotubes with a diameter of 30nm)

[0032] Include the following steps:

[0033] a. Ultrasonic cleaning the titanium material with acetone, absolute ethanol, and deionized water for 20 minutes in sequence, and drying at 37°C for later use;

[0034] b, dissolving ammonium fluoride with a volume fraction of 50% ethanol solution to make a solution with a concentration of 0.27mol / L, as the electrolyte; then the titanium material pretreated in step a is used as the anode, and the platinum electrode is used as the cathode. In the above-mentioned ammonium fluoride electrolyte, electrolyze for 3 hours under the action of a direct current of 10V, soak and wash the oxidized titanium material with deionized water for 3 times, and dry at 37°C to obtain TiO with a diameter of 30nm on the surface. 2 The titanium material of the nanotube array, its FE-SEM image is as follows figure 1 shown;

[0035...

Embodiment 2

[0040] Embodiment 2, biofunctionalized nano-titanium material (TiO 2 Preparation of nanotubes with a diameter of 60nm)

[0041] Include the following steps:

[0042] a. Ultrasonic cleaning the titanium material with acetone, absolute ethanol, and deionized water for 20 minutes in sequence, and drying at 37°C for later use;

[0043] b, dissolving ammonium fluoride with a volume fraction of 50% ethanol solution to make a solution with a concentration of 0.27mol / L, as the electrolyte; then the titanium material pretreated in step a is used as the anode, and the platinum electrode is used as the cathode. In the above-mentioned ammonium fluoride electrolyte, electrolyze for 3 hours under the action of a direct current of 20V, soak and wash the oxidized titanium material with deionized water for 3 times, and dry at 37°C to obtain TiO with a diameter of 60nm on the surface. 2 The titanium material of the nanotube array, its FE-SEM image is as follows figure 2 shown;

[0044]...

Embodiment 3

[0046] Embodiment 3, biofunctionalized nano-titanium material (TiO 2 Preparation of nanotubes with a diameter of 100nm)

[0047] Include the following steps:

[0048] a. Ultrasonic cleaning the titanium material with acetone, absolute ethanol, and deionized water for 20 minutes in sequence, and drying at 37°C for later use;

[0049] b, dissolving ammonium fluoride with a volume fraction of 50% ethanol solution to make a solution with a concentration of 0.27mol / L, as the electrolyte; then the titanium material pretreated in step a is used as the anode, and the platinum electrode is used as the cathode. In the above-mentioned ammonium fluoride electrolyte, electrolyze for 3 hours under the action of a direct current of 25V, soak and wash the oxidized titanium material with deionized water for 3 times, and dry at 37°C to obtain TiO with a diameter of 100nm on the surface. 2 The titanium material of the nanotube array, its FE-SEM image is as follows image 3 shown;

[00...

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Abstract

The invention belongs to the field of biomedical materials, and relates to a biological functionalized nano titanium material. The surface of the titanium material is provided with a TiO2 nano tube array with tube diameter of 30-100nm, and the surface of the TiO2 nano tube array is also fixed with a bone morphogenetic protein 2(BMP2). A preparation method of the biological functionalized nano titanium material comprises the steps of: preparing the TiO2 nano tube array with the tube diameter of 30-100nm on the surface of the titanium material by adopting an anode oxidizing method, and fixing the BMP2 on the surface of the TiO2 nano tube array through polydopamine to obtain the biological functionalized nano titanium material. The biological functionalized nano titanium material has better biocompatibility; on one hand, the TiO2 nano tube array with proper tube diameter can provide a proper topological structure for the cell growth, on the other hand, the BMP2 is used as a growth factor capable of promoting the cell differentiation, and the proliferation and differentiation capacity of the cells on the surface of the titanium material can be improved through the synergistic effect of the topological structure and the chemical components, thus the osseointegration of the titanium material is improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, relates to a biofunctionalized nano titanium material, and also relates to a preparation method of the titanium material. Background technique [0002] In the early 1940s, Bothe and others implanted titanium into the femur of mice and found that there was no adverse reaction between it and the bone, thus introducing titanium into the field of biomedical materials. Since titanium implants were widely used in the field of stomatology in the 1960s, titanium as an implant material has been continuously developed, and with the deepening of research, titanium is generally considered to be a promising medical implant material. [0003] Because titanium and titanium alloys are biologically inert and have poor osseointegration, they cannot be well integrated with the surrounding tissues of the human body, and have disadvantages such as long healing time and poor initial stability, resulting in a low su...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06C25D11/26
Inventor 蔡开勇来敏陈秀勇
Owner CHONGQING UNIV
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