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Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat

A composition and pharmaceutical preparation technology, applied in the field of medicine, can solve problems such as undiscovered, undiscovered prevention and treatment, and achieve the effects of short production cycle, high development and utilization value, and strong operability

Active Publication Date: 2011-05-18
吉林修正药业新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Before the completion of the present invention, there was no literature report on the pharmaceutical composition composed of peltaside, syringin, and syringic acid, which can prevent and treat alcoholic liver damage, alcoholic fatty liver, non-alcoholic fatty liver and There are no reports of hyperlipidemia, and no clinical application of this composition for the prevention and treatment of alcoholic liver injury, alcoholic fatty liver, non-alcoholic fatty liver and hyperlipidemia has been found
At the same time, no composition consisting of glucoside, syringin, and syringic acid extracted from other natural Chinese medicinal materials has been found.

Method used

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  • Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat
  • Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat
  • Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0059] Grind 2kg of the medicinal material of Jiubing into a coarse powder, reflux extraction with 70% ethanol of 8 times the weight of the medicinal material for 3 times, each time for 2 hours, filter, combine the filtrate, recover the ethanol to 2500ml, filter, and take the filter cake Extract I was obtained; the filtrate was evaporated until there was no alcohol smell, passed through the treated D101 macroporous resin column, washed with water until colorless, and then eluted 4BV with 50% ethanol, collected ethanol eluate, recovered ethanol, concentrated, The extract II was obtained; the extract I and the extract II were combined and dried to obtain 158.6 g of the JJBing pharmaceutical composition. Using high performance liquid chromatography to measure and calculate, syringin accounted for 23.8%, catechin glycoside accounted for 59.1%, and betamic acid accounted for 2.9%.

example 2

[0061] Grind 2kg of the medicinal material of Jiubing into a coarse powder, reflux extraction with 50% ethanol of 6 times the weight of the medicinal material for 3 times, each time for 3 hours, filter, combine the filtrate, recover the ethanol to 2500ml, filter, and take the filter cake Extract I was obtained; the filtrate was evaporated until there was no alcohol smell, passed through the treated D101 macroporous resin column, washed with water until colorless, and then eluted with 60% ethanol to elute 4BV, collected ethanol eluate, recovered ethanol, concentrated, The extract II was obtained; the extract I and the extract II were combined and dried to obtain 168.4 g of the JJBing pharmaceutical composition. Using high performance liquid chromatography to measure and calculate, syringin accounted for 19.7%, catechin glycoside accounted for 55.3%, and betamic acid accounted for 2.2%.

example 3

[0063] Grind 2 kg of the medicinal material of Jiubing into a coarse powder, reflux extract twice with 80% ethanol of 8 times the weight of the medicinal material, for 3 hours each time, filter, combine the filtrate, recover the ethanol to 2500ml, filter, and take the filter cake Extract I was obtained; the filtrate was evaporated until it had no alcohol smell, passed through the treated AB-8 macroporous resin column, washed with water until it was colorless, and then 40% ethanol was used to elute 4BV, the ethanol eluate was collected, and ethanol was recovered. Concentrate to obtain extract II; combine extract I and extract II, and dry to obtain 148.6 g of JJBing pharmaceutical composition. Using high-performance liquid chromatography to measure and calculate, syringin accounts for 23.4%, pelicin accounts for 60.1%, and betamic acid accounts for 3.4%. Example 4

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Abstract

The invention discloses an ilicis routundae cortex medicinal composition for preventing and treating alcoholic liver damage, alcoholic fatty liver, non-alcoholic fatty liver and hyperlipidemia. The composition is extracted and refined from natural ilicis routundae cortex and is not chemically modified, and is characterized by comprising substances such as pedunculoside, syringin, rotundicacid and the like. The invention also discloses a preparation method of the ilicis routundae cortex composition and application to preparation of a medicament for preventing and treating the alcoholic liver damage, the alcoholic fatty liver and the non-alcoholic fatty liver and lowering blood fat.

Description

technical field [0001] The present invention relates to a new method and medical use of a pharmaceutical composition extracted from Ilicis routundae cortex, in particular to a drug with the functions of preventing and treating alcoholic liver damage, alcoholic fatty liver, non-alcoholic A pharmaceutical composition for fatty liver and hyperlipidemia. It also relates to the pharmaceutical preparation of the medicine, and the invention belongs to the technical field of medicine. Background technique [0002] Fatty liver is not an independent disease, but a fatty degeneration of the liver caused by various diseases and causes. The most common causes are obesity and alcoholism, followed by malnutrition, diabetes, drug poisoning, pregnancy, and genetics. Hepatic steatosis can affect liver function, and some patients may further develop into hepatitis, liver fibrosis and cirrhosis. The incidence of fatty liver in my country is gradually increasing. Although there is no disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/16A61K31/56A61K31/7034A61K31/7042
Inventor 赵全成南敏伦赫玉芳赵昱玮王莲萍李刚
Owner 吉林修正药业新药开发有限公司
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