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Application of oceanic collagen peptide in preparation of drunkenness preventing medicaments, health-care food or food

A technology of marine collagen peptides and health food, applied in dairy products, food preparation, milk preparations, etc., can solve the problem of lack of marine collagen peptides

Inactive Publication Date: 2011-05-11
李勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no report on the application of marine collagen peptides in drugs, health foods and foods for the prevention of drunkenness

Method used

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  • Application of oceanic collagen peptide in preparation of drunkenness preventing medicaments, health-care food or food
  • Application of oceanic collagen peptide in preparation of drunkenness preventing medicaments, health-care food or food
  • Application of oceanic collagen peptide in preparation of drunkenness preventing medicaments, health-care food or food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1, climbing experiment

[0013] 1. Method:

[0014] 48 clean-grade SD rats, half male and half male, 400-500 g male and 300-400 g female, were provided by the Experimental Animal Center of Peking University Health Science Center. Animals were reared in a clean-grade animal room with an ambient temperature of 25°C and a humidity of 40-60%. The rats were randomly divided into 4 groups according to body weight, namely the positive control group and three doses of marine collagen peptide intervention groups, 12 in each group, half male and half male. After fasting for 4-6 hours, the animals at all levels were administered by intragastric administration. The positive control group was given 0.1ml / kg.bw of distilled water to the rats at one time, and the three dose groups of low, middle and high doses were given marine collagen peptide at one time. 2.25g / kg.bw, 4.5g / kg.bw, 9.0g / kg.bw, equivalent to 50, 100, 200 times the recommended human dose. After 30 minutes,...

Embodiment 2

[0019] Embodiment 2, rotating rod experiment

[0020] 1. Method:

[0021] 48 clean-grade SD rats, half male and half male, 400-500 g male and 300-400 g female, were provided by the Experimental Animal Center of Peking University Health Science Center. Animals were reared in a clean-grade animal room with an ambient temperature of 25°C and a humidity of 40-60%. The rats were randomly divided into 4 groups according to their body weight, namely the positive control group and the low, medium and high doses of marine collagen peptide intervention groups, with 24 rats in each group, half male and half male. The intervention groups of low, medium and high doses were given different doses of marine collagen peptide 2.25g / kg.bw, 4.5g / kg.bw, 9.0g / kg at one time according to the intragastric administration volume of 0.1ml / kg.bw. bw (equivalent to 50, 100, and 200 times the recommended human dose), the control group was given 0.1ml / kg.bw distilled water once. After 30 minutes, each gr...

Embodiment 3

[0027] Embodiment 3, righting reflex experiment

[0028] 1. Method:

[0029]Thirty-six SPF grade SD female rats, weighing 300-400 grams, were randomly divided into 4 groups according to body weight, which were the control group and three doses of marine collagen peptide intervention groups. After fasting for 4-6 hours, the animals in each group were administered by intragastric administration, and the three intervention dose groups of low, medium and high were given collagen peptides 2.25g / kg.bw, 4.5g / kg.bw, 9.0 g / kg.bw, which is equivalent to 50, 100, and 200 times the recommended human dose. The rats in the control group were given 0.1ml / kg.bw of distilled water. After 30 minutes, each group was intragastrically administered 56% ethanol 15.4ml / kg.bw (the actual intake of ethanol was 7g / kg). Whether the righting reflex disappears or recovers is used as an index to observe the drunk and sober state of the rats. After the rats were given alcohol, put their backs down gently ...

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Abstract

The invention discloses application of oceanic collagen peptide in preparation of drunkenness preventing medicaments, health-care food or food. The oceanic collagen peptide is easy to absorb, and has the characteristics of quick absorption, low viscosity, good water solubility and the like; and the prophylactic oceanic collagen peptide can improve the symptoms of muscle weakness and ataxia caused by acute ethanol intake to a certain extent, reduces drunkenness rate, lightens drunkenness symptoms, and has the drunkenness preventing function. When the oceanic collagen peptide is applied in preparation of the drunkenness preventing medicaments, the health-care food or the food, the oceanic collagen peptide has important scientific value and economic benefit, and provides a new path for preventing drunkenness through diets.

Description

technical field [0001] The invention relates to a new application of marine collagen peptide, specifically refers to the application of anti-drunk medicine, health food or food, and belongs to the field of medicine and food health care. Background technique [0002] Acute alcoholism, commonly known as drunkenness, is caused by excessively high concentrations of ethanol in the blood entering the brain in a short period of time, inhibiting the cerebral cortex, causing the subcortical center to lose control, and the central nerve cells to respond and transmit various information. A series of pathological changes are produced, and corresponding clinical symptoms appear. Alcoholism can be roughly divided into 3 stages, namely excitement, ataxia, and lethargy. Ethanol is highly fat-soluble and can enter the brain through the blood-brain barrier, and its concentration in the brain is not much different from that in the blood. When excess ethanol enters the body, it exceeds the ox...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61P39/02A23L1/305A23C9/00A23L1/20A21D2/26A23L33/18
Inventor 李勇梁江王军波
Owner 李勇
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