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Method for preparing perhexiline pharmaceutical preparation

The technology of a pharmaceutical preparation, Guanxinning, is applied in the field of preparation of traditional Chinese medicine preparations, which can solve problems such as difficult quality control and poor drug stability, and achieve the effects of improving drug efficacy, increasing coronary artery flow and myocardial blood flow, and improving myocardial ischemia. Effect

Active Publication Date: 2011-05-11
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is simple and easy to operate, but the stability of the drug is poor, and the quality is not easy to control, especially the clinical efficacy needs to be further improved

Method used

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  • Method for preparing perhexiline pharmaceutical preparation
  • Method for preparing perhexiline pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 20000g of Salvia miltiorrhiza, crush it, add 6 times the amount of crude drug to decoct 3 times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, recover under reduced pressure, and inject the obtained concentrated solution into D101 type macroporous adsorption resin column, first eluted with purified water of 6 times the volume of the column, then eluted with 15% (v / v) ethanol of 6 times the volume of the column, discarded the eluent, and then used 60% ( v / v) ethanol elution, collecting 5 times the column volume of the eluent; concentrating the obtained eluent, drying, and pulverizing to obtain the salvia miltiorrhiza extract;

[0023] Take 20000g of Rhizoma Chuanxiong medicinal material, pulverize, add 60% (v / v) ethanol of 6 times the amount of crude drug, and heat and reflux extraction for 3 times, each time for 2 hours; combine the extracts, recover the solvent under reduced pressure; inject the obtained c...

Embodiment 2

[0032] Take 20,000g of Salvia miltiorrhiza, crush it, add 8 times the crude drug amount of water and decoct twice, the first time for 2 hours, and the second time for 1.5 hours, combine the decoction, filter, recover under reduced pressure, and inject the obtained concentrated solution into the HPD100 large Pore ​​adsorption resin column, first eluted with purified water of 5 times the volume of the column, then eluted with 20% ethanol of 4 times the volume of the column, discarded the eluent, and then eluted with 80% alcohol, collected 6 times the volume of the column volume of eluate; the obtained eluate is concentrated, dried and pulverized to obtain the salvia miltiorrhiza extract;

[0033] Take 20000g of Rhizoma Chuanxiong medicinal material, pulverize, add 80% ethanol of 8 times the amount of crude drug, heat and reflux extraction twice, each time for 2 hours; combine the extracts, recover the solvent under reduced pressure; inject the obtained concentrated solution into ...

Embodiment 3

[0041] Take 2000g of Salvia miltiorrhiza, crush it, add 5 times the crude drug amount of water and decoct 4 times, the first time for 2 hours, the second and third times for 1.5 hours each, and the fourth time for 1 hour each, combine the decoction, filter, and recover under reduced pressure , the concentrated solution obtained is injected into the HP-20 type macroporous adsorption resin column, first eluted with purified water of 7 times the volume of the column, then eluted with 20% ethanol 8 times the volume of the column, discarded the eluent, and then Elute with 75% ethanol, collect 8 times the column volume of the eluate; concentrate the obtained eluate, dry, and pulverize to obtain the salvia miltiorrhiza extract;

[0042] Take 2000g of Rhizoma Chuanxiong medicinal material, pulverize, add 70% ethanol of 10 times the amount of crude drug, heat and reflux extraction for 3 times, each time for 2 hours; combine the extracts, recover the solvent under reduced pressure; injec...

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Abstract

The invention discloses a preparation method of a perhexiline pharmaceutical preparation, comprising the following steps of: (a) preparing pharmaceutical components salvia and szechuan lovage rhizome, wherein the weight ratio of salvia to szechuan lovage rhizome 1-3: 1-3 by weight; (b) decocting the salvia, injecting concentrated liquor in a macroporous absorption resin column, and concentrating and drying eluent to obtain salvia extractive; (c) decocting the szechuan lovage rhizome, injecting concentrated liquor in a macroporous absorption resin column, and concentrating and drying eluent to obtain szechuan lovage rhizome extractive; and (d) adding pharmacologically allowed pharmaceutical carriers in the prepared extractives uses as active ingredients to prepare various forms of pharmaceutical preparation. The perhexiline pharmaceutical preparation prepared by the method disclosed in the invention has effect superior to that of the perhexiline pharmaceuticals prepared according to the prior art.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of a traditional Chinese medicine preparation composed of active ingredients of salvia miltiorrhiza and chuanxiong. Background technique [0002] Guanxinning injection is a traditional Chinese medicine preparation containing effective extracts of Danshen and Chuanxiong. It has been developed into a water injection in the 1970s and has been on the market in China for more than 30 years. It is a traditional Chinese medicine injection commonly used in clinical treatment of cardiovascular and cerebrovascular diseases. It can improve coronary circulation and anticoagulation, and can significantly increase coronary blood flow. Improve myocardial blood supply, prevent and reduce the formation of thrombus, and reduce the scope of embolism. It is mainly used for the treatment of coronary heart disease and angina pectoris. The curr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10
Inventor 孔德宪姜海卢树杰
Owner SHINEWAY PHARMA GRP LTD
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