Application of tulasi extract in preparation of medicament for treating radiation injuries

A technology of radiation damage and extracts, which is applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., to achieve good drug safety, improve survival rate, and reduce radiation damage.

Inactive Publication Date: 2011-05-11
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about the application of Tulasi extract in the preparation of medicines for the treatment of radiation damage and protection

Method used

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  • Application of tulasi extract in preparation of medicament for treating radiation injuries
  • Application of tulasi extract in preparation of medicament for treating radiation injuries
  • Application of tulasi extract in preparation of medicament for treating radiation injuries

Examples

Experimental program
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Effect test

Embodiment 1

[0018] The experimental animal Swiss mouse (Swiss albino mice) used in the examples was provided by the Animal Experiment Center of Soochow University.

[0019] The reagents and instruments used in the examples include: Reagents: Tulasi leaf extract is provided by Suzhou Kimov Drug Development Co., Ltd., High-tech Zone, Suzhou City, Jiangsu Province. Malondialdehyde (Malondialdehyde, MDA) assay kit, reduced glutathione (Glutathione, GSH) assay kit, coomassie bright blue protein assay kit were all provided by Nanjing Jiancheng Bioengineering Institute. Instrument: Model 722 visible spectrophotometer is produced by Shanghai Second Instrument Factory.

[0020] use 137 Cs-γ ray irradiated mice with different doses of a single whole body, and used the maximum tolerated dose to evaluate the drug safety of Tulasi, and observed the 30-day survival rate of mice, liver malondialdehyde (MDA) and reduced glutathione (Glutathione, GSH) content.

[0021] In the above technical scheme, th...

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Abstract

The invention belongs to the field of preparation of a medicament for treating radiation injuries, in particular to an application of a tulasi extract in preparation of a medicament for treating radiation injuries, and further discloses a medicament for treating radiation injuries, wherein the main active ingredient of the medicament for treating the radiation injuries is the tulasi leaf extract. The invention simultaneously discloses a radiation protective agent, and the main active ingredient of the radiation protective agent is the tulasi leaf extract. As the tulasi extract has the advantages of medical secuiry, anti-free radicals and radiation protection role, the tulasi extract can be used for preparing the medicament for treating the radiation injuries and the radiation protective agent, and alleviate the radiation injuries to clinical patients undergoing radiotherapy and staff suffering high-dose radiation in a nuclear accident.

Description

technical field [0001] The invention belongs to the field of preparation of medicines for treating radiation damage, and in particular relates to the application of tulasi extract in preparing medicines for treating radiation damage. Background technique [0002] At present, there are few radioprotective drugs used clinically, and most of them are chemically synthesized. The serious side effects limit their wide application. Tulasi is an annual herb growing in subtropical regions. It is called Holy Basil, Tulasi, and Tulasi (also known as Ocimum sanctum, Holy basil) in China. Its stems, leaves, and seeds can be used as medicine and are easy to grow. , is cheap, and the water and ethanol extracts of its leaves are commercially available. Studies have proved that the water extract and ethanol extract of Tulasi leaves have antioxidant, bactericidal, anti-inflammatory, anti-mutation effects, and have been widely used in the treatment of coronary heart disease, neurodegenerative...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P17/16A61P39/06A61K127/00
Inventor 樊赛军王利利
Owner SUZHOU UNIV
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