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Veterinary yeast glucan injection

A technology of yeast glucan and injection, which can be used in medical preparations containing active ingredients, drug delivery, antibacterial drugs, etc., and can solve problems that have not yet been seen

Inactive Publication Date: 2012-10-17
天津市农业科学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are carboxymethyl water-soluble yeast glucan products for sale, which are mainly used as biological additives in the production of cosmetics, but there is no relevant information about preparing yeast glucan into veterinary yeast glucan injection through the injection route Literature Reports Applied to Mammalian Research

Method used

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  • Veterinary yeast glucan injection
  • Veterinary yeast glucan injection
  • Veterinary yeast glucan injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Add 99% n-propanol into a beaker, put it in a constant temperature water bath whose temperature drops to -15°C, and slowly drop an equal amount of concentrated sulfuric acid into n-propanol with an acid burette when the temperature drops to -15°C , stirred while dropping, fully mixed, and prepared into a sulfonation reaction liquid. Add yeast dextran to the above reaction solution and react at -15°C for 2 hours. Immediately after the reaction, centrifuge at -10°C and 14000r / min for 12min to remove the reaction solution. The precipitate was washed with pre-cooled n-propanol for 3 times, then dissolved in deionized water, centrifuged to remove the unreacted yeast dextran precipitate, and the supernatant was collected and freeze-dried to obtain white powder sulfated yeast Dextran. Determined by the phenol-sulfuric acid method, the color of the sample is orange-yellow, indicating that the sulfated yeast glucan obtained above is sulfated dextran; judging according to the d...

Embodiment 2

[0089] Carboxymethyl water-soluble yeast dextran 2g, sterilized and dissolved in 97ml of water for injection, subpackaged and sealed is the injection.

Embodiment 3

[0091] Carboxymethyl water-soluble yeast dextran 4g, dissolved in 96ml of water for injection after sterilization, sub-packaged and sealed is the injection.

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Abstract

The invention discloses veterinary yeast glucan injection, and aims to provide an animal immunopotentiator, which is prepared from yeast glucan through chemical modification and is a purely natural green veterinary medicine product. Each 100ml of injection contains 2 to 24g of sulfated or carboxymethyl water-soluble yeast glucan and the balance of water for injection. The injection can nonspecifically enhance the immunity of animals such as rabbits, pigs, sheep, cows and the like and improve the anti-infection capability of the animals. The preparation prepared by the invention is injection and has the advantages of no toxic or side effects, no residues and the like, is convenient to use and meets the current development requirements of green products.

Description

technical field [0001] The invention belongs to the technical field of veterinary pharmaceutical preparations, and relates to the application of water-soluble yeast glucan in livestock and poultry through injection, more specifically, a veterinary yeast glucan injection and its preparation and application method. technical background [0002] In the 1940s, Dr. Pillemer first discovered and reported that a substance in the cell wall of yeast can enhance immunity. Afterwards, further research by Dr. Diluzio from the University of Tulum found that what improves immunity in the yeast cell wall is a polysaccharide of glucan, mainly composed of β-1, 3-D glucan, because it can It enhances the immunity of mammals, and at the same time has the functions of anti-cancer, anti-bacteria, anti-virus, anti-fungal, anti-parasite, lowering cholesterol and blood lipid, promoting wound healing, etc., and is known as a biological effect responder. [0003] The yeast glucan extracted from the y...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61K31/716A61K9/08A61P31/04
Inventor 王英珍孙英峰冯建忠池晶晶张健王东李秀丽任卫科张效生张金龙王建国张莉王成龙张廷青
Owner 天津市农业科学院
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