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Intestine positioning preparation of glycyrrhetic acid, glycyrrhetinic acid and salts of glycyrrhetic acid and glycyrrhetinic acid, and preparation method and application thereof

Inactive Publication Date: 2011-04-20
WUHAN WORLDNER UNITED PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The first object of the present invention is to provide a colon-localized preparation of glycyrrhizic acid, glycyrrhetinic acid and its salt compounds and its application, which can effectively solve the drug dosage of existing glycyrrhizic acid, glycyrrhetinic acid and its salt compounds Large, inaccurate curative effect, and certain side effects, to achieve the purpose of increasing efficiency and reducing toxicity

Method used

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  • Intestine positioning preparation of glycyrrhetic acid, glycyrrhetinic acid and salts of glycyrrhetic acid and glycyrrhetinic acid, and preparation method and application thereof
  • Intestine positioning preparation of glycyrrhetic acid, glycyrrhetinic acid and salts of glycyrrhetic acid and glycyrrhetinic acid, and preparation method and application thereof
  • Intestine positioning preparation of glycyrrhetic acid, glycyrrhetinic acid and salts of glycyrrhetic acid and glycyrrhetinic acid, and preparation method and application thereof

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Embodiment Construction

[0022] See the figures at figure 1 Among them, 1 is the drug-loaded pellet core, 2 is the isolation layer, 3 is the enzyme-sensitive coating layer, and 4 is the pH-sensitive coating layer.

[0023] What the present invention describes is an intestinal targeting preparation of glycyrrhizic acid, glycyrrhetinic acid and its salts. .

[0024] The intestinal localization preparation refers to: ileocecal and / or colon localization preparation.

[0025] Moreover, diammonium glycyrrhizinate is a glycyrrhizic acid α-body preparation.

[0026] Another technical solution of the present invention is: a preparation method of an intestinal-localized preparation of glycyrrhizic acid, glycyrrhetinic acid and salts thereof, the difference being:

[0027] 3.1 Prepare drug-loaded pellet core 1 by spraying liquid on the blank pellet core in a fluidized bed, and cure it at 40-45°C for 2-3 hours;

[0028] 3.2 Opadry-OPADRY (commercially available trade name, is a kind of containing hydroxypropy...

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Abstract

The invention discloses an intestine positioning preparation of glycyrrhetic acid, glycyrrhetinic acid and salts of glycyrrhetic acid and glycyrrhetinic acid, a preparation method thereof and application thereof. The key point is to wrap glycyrrhetic acid or glycyrrhetinic acid or diammonium glycyrrhizinate and salt compounds thereof in the intestine positioning preparation. The preparation method comprises the following steps of: spraying a liquid medicament onto empty pill cores in a fluidized bed to prepare medicament carrying pill cores, and then wrapping an isolation layer, an enzyme sensitive coating and a pH sensitive coating on the pill cores. The preparation is applied to the preparation of medicaments for treating inflammatory bowel diseases, hepatitis, rheumatoid arthritis, asthma, bronchitis and skin inflammation.

Description

technical field [0001] The invention relates to an intestinal-localized preparation of glycyrrhizic acid, glycyrrhetinic acid and salts thereof, a preparation method and application thereof, which can be used for preparing medicines for treating inflammatory bowel disease, hepatitis, rheumatoid arthritis, asthma, bronchitis and skin inflammation application. Background technique [0002] Oral colon specific dury delivery system (OCSDDS), also known as colonic delayed-release preparation, is a new drug delivery system developed in the late 1970s. Due to mild pH conditions and few metabolic enzymes in the colon, drug release at this site can reduce the destructive effect of gastrointestinal digestive enzymes on the drug, improve the bioavailability of the drug absorbed in the colon, and improve the effect on colon lesions (such as ulcerative colon disease). Inflammation, colon cancer, etc.), especially for the administration of degraded protein and peptide drugs in the upper ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/36A61K9/62A61K31/704A61K31/56A61P1/00A61P1/16A61P19/02A61P29/00A61P11/06A61P11/00A61P17/00
Inventor 丁虹齐哲琼
Owner WUHAN WORLDNER UNITED PHARMA
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