Quetiapine fumarate tablet and preparation method thereof

A quetiapine fumarate tablet and a technology for quetiapine fumarate, which are applied in the field of medicine, can solve the problems of poor particle fluidity, unstable tablet weight, and difficulty in controlling the quality of preparations, and achieve good fluidity. Effect

Inactive Publication Date: 2011-03-30
SHANGHAI CHENPON PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation of the above tablets, the addition of lactose makes the fluidity of the granules poor during the granulation process, making it difficult to control the quality of the preparations, and the tablet weight is unstable

Method used

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  • Quetiapine fumarate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Quetiapine fumarate tablets (on a scale of 1000 tablets) according to the following components and prescription quantities: 230.26 g of quetiapine fumarate, 130.74 g of starch, 40.00 g of calcium hydrogen phosphate, and 50.00 g of microcrystalline fiber Sodium hydroxymethyl starch 35.00g, povidone 15.00g, magnesium stearate 5.00g.

[0057] Preparation of tablet cores:

[0058] 1) Pass quetiapine fumarate through a 80-mesh sieve, microcrystalline cellulose, starch, calcium hydrogen phosphate and hydroxymethyl starch sodium pass through a 24-mesh sieve respectively, magnesium stearate pass through a 40-mesh sieve, and povidone is dissolved in In 95% ethanol, the concentration is about 15%, for later use;

[0059] 2) The quetiapine fumarate, starch, microcrystalline cellulose, calcium hydrogen phosphate and sodium hydroxymethyl starch in step 1) are wet granulated; then the ethanol solution of povidone is added for granulation to obtain soft material;

[0060] 3) The so...

Embodiment 2-3

[0075] Quetiapine fumarate tablets were prepared according to the components and recipe quantities in the following table, and the preparation method was the same as in Example 1.

[0076]

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Abstract

The invention relates to a quetiapine fumarate tablet and a preparation method thereof. The tablet of the invention comprises quetiapine fumarate, a filler, a disintegrant, povidone and magnesium stearate in certain proportions. The preparation method comprises the following steps: granulating the quetiapine fumarate, the filler and the disintegrant by a wet method; then adding the povidone and granulating into a soft material; screening, drying and finishing the soft material; adding the magnesium stearate and mixing; measuring the content and calculating the tablet weight; and respectively tabletting and coating to obtain the quetiapine fumarate tablet. The tablet can be used for treating schizophrenia. By using the formula provided by the invention, the defect of poor particle mobility during granulating in the prior art is overcome.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical preparation and a preparation method thereof, in particular to a quetiapine fumarate tablet and a preparation method thereof. Background technique [0002] Quetiapine fumarate, whose chemical name is 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4] Thiazepine hemifumarate, an atypical antipsychotic drug, is similar in structure to clozapine and olanzapine, and has interactions with multiple neurotransmitter receptors. In the brain, quetiapine fumarate has an effect on serotonin (5HT 2 ) receptors have a high affinity, and greater than the affinity for dopamine D1 and dopamine D2 receptors in the brain. Quetiapine fumarate also has high affinity for histamine receptors and adrenergic α1 receptors, has low affinity for adrenergic α2 receptors, but has a low affinity for cholinergic muscarinic receptors or benzodiazepines. Azepine receptors have essentially ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/554A61K47/36A61K47/32A61K47/38A61P25/18
Inventor 王丹吴晓毅杜狄峥
Owner SHANGHAI CHENPON PHARM TECH CO LTD
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