Compound preparation for treating diseases caused by poultry sensitive bacteria and preparation method thereof

Abstract

The invention relates to a compound preparation for treating diseases caused by poultry sensitive bacteria and a preparation method thereof. The compound preparation is a long-acting injectable suspension prepared from florfenicol and occrycetin as main medicines and comprises 2.0-20.0% (W / V) of florfenicol, 5.0-30.0% (W / V) of occrycetin, 0.05-0.40% (W / V) of antioxidant, 1-10% (W / V) of antiallergic factor synergist, 0.01-0.04% (W / V) of complexing agent, 0.01-15% (W / V) of suspending agent, 1.0-10.0% (W / V) of flocculating agent, 0.01-0.5% (W / V) of preservative and 60-100% (W / V) of water for injection. The liquid medicine of the invention has stable performance and can effectively overcome the defects of instable performance, easy color change, precipitation and failure and the like of injections. The compound preparation has small irritativeness, low cost and simple process and can prolong the residence time of medicine in body and increase the bioavailability of the medicine. The compound preparation can be used for preventing and treating infectious diseases caused by poultry sensitive bacteria, such as pasteurellosis, colibacillosis, salmonellosis, contagious pleuropneumonia, mycoplasmlpneumonia of swine, acute respiratory infection and the like.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a long-acting injectable compound suspension for treating diseases caused by sensitive bacteria in livestock and poultry and a preparation method thereof. The compound preparation is used for preventing and treating diseases caused by sensitive bacteria in livestock and poultry. Infections such as pasteurellosis, colibacillosis and salmonellosis, contagious pleuropneumonia, swine panting, acute respiratory infections, etc. Background technique [0002] At present, with the long-term use of antibiotics, livestock and poultry are facing a huge threat of drug resistance, and the drug resistance of pathogenic bacteria is increasing year by year, resulting in a decline in curative effect and an increase in dosage. Clinically, it often manifests as a complicated condition and multiple mixed infections. Therefore, the development of safe, high-efficiency, and br...

AI Technical Summary

Problems solved by technology

[0006] In addition, oxytetracycline hydrochloride and florfenicol currently sold in the market are mostly unilateral injections, and there is no long-acting suspension product, and oxytetracycline hydrochloride injection has unstable performance, easy discoloration, precipitation, failure, and is made into The properties of the suspension will change significantly, and there is a great risk in the use of the injection. A large amount of organic solvents are placed in the preparation, which will cause greater irritation and pain to the animal body, and the suspension can prolong the drug. The residence time in the body improves the bioavailability of the drug, and the preparation method of the preparation is simple and the cost is low

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