Mangnolia officinalis alkaloid, extraction method and applications thereof

An extraction method and alkaloid technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effect of low cost, no environmental pollution, and simple extraction process

Inactive Publication Date: 2011-02-09
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its antibacterial activity can be used for oral care, as publication number is CN101321513, CN101321560, CN1723011, CN1318362, the patent report of CN101222909 application in the oral cavity, so far, there is no α-glucosidase inhibition in Magnolia officinalis Active ingredient reporting

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Magnolia officinalis bark 10kg, percolation extraction with 60L 0.05% sulfuric acid water after crushing. The extract was passed through a D72 macroporous cation exchange resin column (column volume 6L), washed with 20L of deionized water and then eluted with 30L of 1% ammonia / ethanol water (containing 70% ethanol) solution. The eluate was evaporated to dryness to obtain 30 g of total alkaloids with a yield of 0.3%.

[0017] Take 4.0 g of total bases, separate and purify through silica gel column chromatography (chloroform-methanol gradient elution) to obtain five compounds, which are identified as magnolialine, liriodendronine, and anthracine by mass spectrometry, carbon nuclear magnetic resonance spectrum and hydrogen spectrum , Romer's base and Lysicamine.

[0018] Get total alkaloids 50g of magnolia bark, add starch 3000g, microcrystalline cellulose 30g, granulate with 50% ethanol, compress to obtain tablet, every 0.6g, wherein contain total alkaloids 10mg, be equi...

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PUM

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Abstract

The invention belongs to the organic chemistry technical field, relating to an extraction method of mangnolia officinalis active constituent alkaloid and applications thereof used as alpha-glucuroide inhibitor. The mangnolia officinalis alkaloid of the invention comprises magnoflorine, liriodenine, anonaine, roemerine and total alkaloids of lysicamine, and mangnolia officinalis bark is taken as a raw material and then is extracted with acid aqueous solution at normal temperature or by heating; the extracting solution passes through strong-acid-type cation exchange resin or weak-acid-type cation exchange resin; and the active component is adsorbed on the resin; the resin column is washed by water, is eluted with ammonia water or alcoholic solution, and the obtained product is concentrated and dried to obtain total mangnolia officinalis alkaloids. The invention has the advantages of simple extraction and preparation process, easy operation and low cost and the like.

Description

technical field [0001] The invention belongs to the technical field of organic chemistry, and relates to a method for extracting alkaloids of magnolia officinalis active ingredients and its application as an alpha-glucosidase inhibitor. Background technique [0002] Diabetes mellitus is a progressive endocrine disease with glucose metabolism disorder as the main symptom group. The basic pathophysiology is the relative deficiency or absolute deficiency of insulin secretion function in the body or the abnormal function of insulin receptor, which causes metabolic disorder, including sugar, protein, Fat, water and electrolytes etc. The general manifestations are hyperglycemia, diabetes and hyperlipidemia. In severe cases, ketoacidemia may occur, and even circulatory attenuation and coma are life-threatening. Diabetes is divided into four categories, of which type II diabetes accounts for 90-95% of the total number of diabetes. The treatment methods of diabetes mainly include d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P3/04A61K135/00A61K125/00A61K129/00A61P11/00A61P31/16A61P3/10A61K36/575
Inventor 王明奎瞿庆喜喻凯
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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