2-methoxy estradiol injectable hydrogel implant
A technology of methoxyestradiol and implants, which is applied in the field of medicine, can solve the problems of strong fat solubility, poor water solubility, and no improvement in the treatment effect, and achieve the effects of improving the treatment effect, easy production and scientific formula
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Embodiment 1
[0008] When the 2-methoxyestradiol injectable hydrogel implant of the present invention is specifically implemented, the percentage by weight is: temperature-sensitive PLGA-PEG-PLGA block copolymer 24.6%, ultrapure water 73.9%, 2-Methoxyestradiol 1.5% is made, wherein first temperature-sensitive PLGA-PEG-PLGA block copolymer and ultrapure water are mixed, put 2 days (48 hours, hereinafter the same at low temperature) in the refrigerator ), to fully swell the temperature-sensitive PLGA-PEG-PLGA block copolymer, add 2-methoxyestradiol and mix well before subcutaneous injection; or mix 0.75g temperature-sensitive PLGA-PEG-PLGA block copolymer The copolymer is mixed with 2.25g of ultrapure water, placed in the refrigerator at low temperature for 2 days, so that the temperature-sensitive PLGA-PEG-PLGA block copolymer is fully swollen, and 0.045g of 2-methoxyestradiol is added before subcutaneous injection Alcohol can be mixed;
[0009] The molecular weight of said temperature-sens...
Embodiment 2
[0011] When the present invention is implemented, it can also be made by weight percentage: temperature-sensitive PLGA-PEG-PLGA block copolymer 14.8%, ultrapure water 83.7%, 2-methoxyestradiol 1.5%, wherein first Mix the temperature-sensitive PLGA-PEG-PLGA block copolymer with ultrapure water, and place it in the refrigerator at low temperature for 2 days to fully swell the temperature-sensitive PLGA-PEG-PLGA block copolymer, 12 hours before use Add 2-methoxyestradiol and mix well before subcutaneous injection; or mix 0.45g of temperature-sensitive PLGA-PEG-PLGA block copolymer with 2.55g of ultrapure water, put it in the refrigerator at low temperature For 2 days, fully swell the temperature-sensitive PLGA-PEG-PLGA block copolymer, add 0.045g of 2-methoxyestradiol 12 hours before use, and mix well before subcutaneous injection;
[0012] The molecular weight of said temperature-sensitive PLGA-PEG-PLGA block copolymer is 4500, the molar ratio of lactic acid:glycolic acid is 6:1...
Embodiment 3
[0014] When the present invention is implemented, it can also be made by weight percentage: temperature-sensitive PLGA-PEG-PLGA block copolymer 24.3%, ultrapure water 72.8%, 2-methoxyestradiol 2.9%, wherein, First mix the temperature-sensitive PLGA-PEG-PLGA block copolymer with ultrapure water, and place it in the refrigerator at low temperature for 2 days to fully swell the temperature-sensitive PLGA-PEG-PLGA block copolymer. Before use, 6 Add 2-methoxyestradiol within 1 hour and mix well before subcutaneous injection; or mix 0.75g of temperature-sensitive PLGA-PEG-PLGA block copolymer with 2.25g of ultrapure water, and put it in the refrigerator at low temperature Leave it for 2 days to fully swell the temperature-sensitive PLGA-PEG-PLGA block copolymer, add 0.090g of 2-methoxyestradiol 6 hours before use, and mix well before subcutaneous injection;
[0015] The molecular weight of said temperature-sensitive PLGA-PEG-PLGA block copolymer is 5000, the molar ratio of lactic ac...
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