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Application of galium verum L. general flavone in preparing medicicament of alpha-glucuronide inhibitor

A technology for the total flavonoids of Cape japonica, which is applied in the field of medicine, and can solve the problems such as the report that the application of the total flavonoids of Cape chinensis has not been found.

Inactive Publication Date: 2011-01-05
吉林天药药物研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Before the completion of the present invention, no report was found on the total flavonoids of Cape japonica as an α-glucosidase inhibitor, nor was there any report on the application of the total flavonoids of Cape japonica in the preparation of α-glucosidase inhibitor medicines

Method used

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  • Application of galium verum L. general flavone in preparing medicicament of alpha-glucuronide inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 1. Extraction and preparation of total flavonoids of Potassium japonica:

[0031]1kg of the medicinal material of Potassium japonica, reflux extraction with 10 times the amount of 70% ethanol containing 3% calcium oxide for 3 times, each time for 2 hours, filter, add 0.5% medicinal active carbon in the filtrate, filter, and the filtrate directly passes through Macroporous resin column, then elute 3BV with 70% ethanol, collect the effluent and eluent, recover the solvent, concentrate to contain 0.5g medicinal material per 1ml, pass through the polyamide resin column, first elute 2BV with water, and then use 60% Eluted with ethanol, collected the 60% ethanol eluate, recovered the solvent, concentrated and dried to obtain the total flavonoids of Cape chinensis. The yield is: 0.75%, and the total flavone content is 86.5%.

Embodiment 2

[0032] Example 2 1. Extraction and preparation of total flavonoids of Potassium japonica:

[0033] 1kg of the medicinal material of Potassium aesculata, reflux extraction twice with 8 times the amount of 60% ethanol containing 4% calcium oxide, each time for 3 hours, filter, add 0.3% medicinal active carbon in the filtrate, filter, and the filtrate directly passes through Macroporous resin column, then elute 3BV with 60% ethanol, collect the effluent and eluate, recover the solvent, concentrate to contain 0.5g medicinal material per 1ml, pass through the polyamide resin column, first elute 2BV with water, and then use 60% Eluted with ethanol, collected the 60% ethanol eluate, recovered the solvent, concentrated and dried to obtain the total flavonoids of Cape chinensis. The yield is: 0.80%, and the total flavone content is 90.2%.

Embodiment 3

[0034] Example 3 1. Extraction and preparation of total flavonoids of Potassium japonica:

[0035] 500g of the medicinal herb of Cape japonica, reflux extraction with 10 times of 70% methanol containing 3% calcium oxide twice, each time for 3 hours, filter, add 0.5% medicinal active carbon in the filtrate, filter, and the filtrate directly passes through Macroporous resin column, then elute 3BV with 70% methanol, collect the effluent and eluent, recover the solvent, concentrate to 0.5g medicinal material per 1ml, pass through the polyamide resin column, first elute 2BV with water, and then use 70% Eluted with methanol, collected 70% methanol eluate, recovered the solvent, concentrated and dried, and obtained the total flavonoids of Potassium chinensis. The yield is: 0.72%, and the total flavone content is 92.6%.

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Abstract

The invention discloses a method of initially preparing a large mount of high-content galium verum L. general flavone from the whole plant of galium verum L. as a Rubiaccac plant by using a macroporous resin and polyamide column chromatography method, and the application of the galium verum L. general flavone in preparing medicaments for reducing blood sugar is firstly proved. More specifically, the invention discloses a new application of the galium verum L. general flavone in preparing medicament of an alpha-glucuronide inhibitor, wherein both the galium verum L. general flavone and a composite containing the galium verum L. general flavone can be used to prepare the medicament of an alpha-glucuroide inhibitor. The invention also introduces the preparations of the galium verum L. general flavone medicaments, which can be tablets, capsules, granular formulation, pills or injection and the like.

Description

technical field [0001] The present invention relates to the new medical application of the total flavonoids of A. japonica, specifically the application of the total flavonoids of A. japonica in the preparation of α-glucosidase inhibitor drugs, and also relates to the extraction and separation of the drugs and pharmaceutical preparations. The present invention It belongs to the field of medical technology. Background technique [0002] Diabetes mellitus is a group of clinical syndromes caused by the interaction of genetic and environmental factors. It is due to the absolute or relative insufficiency of insulin secretion and the decreased sensitivity of target tissues to insulin, which causes a series of metabolism in the body such as sugar, fat, protein, water and electrolytes. Disorder, clinically with hyperglycemia as the main common sign. Prolonged illness can cause multi-system damage, and acute metabolic disorders such as ketoacidosis can occur when the condition is se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P3/10
Inventor 赵全成南敏伦李庆杰马吉胜张瑜赵昱玮张玲赫玉芳
Owner 吉林天药药物研发有限公司
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