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Method for producing immune cells and method for inducing immune effector cells

A technology of immune cells and immune function, applied in biochemical equipment and methods, microorganisms, tissue culture, etc., can solve problems such as infection and virus contamination

Active Publication Date: 2013-05-01
VECTORITE BIOMEDICA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of virus or virus-infected cells as an antigen source has the potential risk of virus contamination and infection; and the use of full-length herpes virus genes or proteins as an antigen source can induce immune suppression or immune resistance. The problem of immunity (immunetolerance)

Method used

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  • Method for producing immune cells and method for inducing immune effector cells
  • Method for producing immune cells and method for inducing immune effector cells
  • Method for producing immune cells and method for inducing immune effector cells

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Embodiment Construction

[0037] Since the present invention discloses a method for producing immune cells and a method for inducing the production of immune cells, the immunological principles, cell culture, cell staining and detection and other related technologies used therein are those with ordinary knowledge in the relevant technical field It can be understood, so the description below will not make a complete description. At the same time, the diagrams compared in the following text are schematic representations related to the features of the present invention, and are not and need not be completely drawn according to the actual situation, so they will be described first.

[0038] The first embodiment of the present invention provides a method for producing immune cells, which includes the following steps: mixing and culturing immune cells and an immunogen composition, and the immunogen composition used contains at least two Peptides of virus type IV. The immune cells can be antigen presenting cel...

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Abstract

The invention discloses a method for producing immune cells and a method for inducing immune effector cells. The method for producing the immune cells comprises the following step: carrying out mixed culture on the immune cells and an immunogen composition, wherein, the immunogen composition comprises at least two types of peptide derived from human herpesvirus-4 or a peptide library and can alsocomprise an immuno-adjuvant. In addition, the method for inducing the immune effector cells: mixing antigen presenting cells with the immunogen composition to obtain a culture; and co-culturing the obtained culture with lymphocyte in an appropriate culture medium to obtain activated immune effector cells, wherein, the culture medium can also comprise the immuno-adjuvant, and the obtained activated immune effector cell can be used for producing anti-EBA (Epstein-Barrvirus) immune reaction.

Description

technical field [0001] The present invention relates to a method for generating immune cells, especially for generating immune cells against herpes virus. Background technique [0002] In 1964, Achong and Barr et al. first isolated and discovered Epstein-Barr Virus (Epstein-Barr Virus, EBV) from the cells of Burch's lymphoma patients. The Chinese name is "Human herpesvirus type IV" (Human herpesvirus -4, HHV-4), a linear double-stranded DNA virus belonging to the family Herpesviridae. [0003] Like most herpes viruses, EBV has two life histories: Lytic phase and Latent phase. Among them, the cell lysis period mostly occurs in epithelial cells, because the virus will replicate in large numbers in the cell, and finally cause the cell to rupture and release a large amount of virus. The incubation period mostly occurs in B lymphocytes. EBV is embedded in the gene body of B lymphocytes to avoid the attack of immune cells. At the same time, it may also cause abnormal proliferati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/08
Inventor 梁莹
Owner VECTORITE BIOMEDICA
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