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Method for preparing nanosilver/nano silicon dioxide-containing antibacterial biological dressing

A technology of nano-silica and biological dressings, applied in the field of preparation of biomedical materials, can solve the problems of high efficiency, large particle size, and wide size distribution that affect antibacterial performance, and achieve the promotion of wound healing, dense and uniform voids, and high porosity Effect

Inactive Publication Date: 2013-09-25
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nano-silver materials prepared by traditional methods have large particle sizes and wide size distributions, which affect the high efficiency of their antibacterial properties.

Method used

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  • Method for preparing nanosilver/nano silicon dioxide-containing antibacterial biological dressing
  • Method for preparing nanosilver/nano silicon dioxide-containing antibacterial biological dressing
  • Method for preparing nanosilver/nano silicon dioxide-containing antibacterial biological dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] In 200 mL of absolute ethanol, add 1.0 g of silicon dioxide dried at 120° C., and stir evenly. 1.0 mL of water and 0.054 g of sodium hydroxide were added, and the mixture was stirred for 24 hours in a constant temperature water bath at 25°C. 20 mL of 7.6 g / L silver nitrate ethanol solution was added dropwise at a constant speed for 30 min, and after 10 min of reaction, centrifuged, washed with ethanol, and dried to obtain silver-loaded silica powder.

[0026] 0.05 g of chitosan was dissolved in a 5% by volume dilute acetic acid aqueous solution to prepare a 1.0% by mass chitosan solution. 0.05 g of polyvinyl alcohol was dissolved in boiling water to prepare a polyvinyl alcohol solution with a mass fraction of 1.0%. The above chitosan solution and polyvinyl alcohol solution are mixed in a volume ratio of 1:1 and then fully stirred to obtain a polyvinyl alcohol / chitosan blended solution. Weigh 20g of polyvinyl alcohol, dissolve it in 200mL of boiling water, cool to 50°C...

Embodiment 2

[0030] In 280 mL of anhydrous ethanol, add 0.5 g of silica dried at 120° C., and stir evenly. 2.0 mL of water and 0.054 g of sodium hydroxide were added, and the mixture was stirred for 24 hours in a constant temperature water bath environment at 25°C. 30 mL of 7.6 g / L ethanol solution of silver nitrate was added dropwise at a uniform speed for 40 min, and after 10 min of reaction, centrifuged, washed with ethanol, and dried to obtain silver-loaded silica powder.

[0031]0.05 g of chitosan was dissolved in a dilute acetic acid aqueous solution with a volume fraction of 5% to prepare a chitosan solution with a mass fraction of 1.0%. Dissolve 0.05 g of polyvinyl alcohol in 5 ml of boiling water to prepare a polyvinyl alcohol solution with a mass fraction of 1.0%. The above chitosan solution and polyvinyl alcohol solution are mixed in a volume ratio of 1:1 and then fully stirred to obtain a polyvinyl alcohol / chitosan blended solution. Weigh 20g of polyvinyl alcohol, dissolve it...

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Abstract

The invention discloses a method for preparing a nanosilver / nano silicon dioxide-containing antibacterial biological dressing, and relates to the field of antibacterial biological dressings. The nanosilver / nano silicon dioxide-containing antibacterial biological dressing is prepared by adding mixed solution of chitosan and polyvinyl alcohol and silver-carried silicon dioxide powder during the acetalation of the polyvinyl alcohol. The nanosilver / nano silicon dioxide-containing antibacterial biological dressing of the invention can accelerate the wound healing, slowly release the silver nanoparticles and continuously act on reproductive bacteria, has the characteristic of durable and high-efficiency sterilization and does not produce medicament resistance; and through the researches on the toxicity of the material to mouse fibroblast cells, the product does not produce obvious toxicity to the cells but promotes the growth of the cells.

Description

technical field [0001] The invention relates to a preparation technology of biomedical materials, in particular to a preparation method of an antibacterial biological dressing containing nano-silver / nano-silica, which is suitable for wound treatment. Background technique: [0002] A medical dressing is a protective covering over a wound to help control bleeding, prevent infection, and absorb secretions. Modern medical biological dressings are new wound repair and protection materials developed on the basis of the theory of "wet healing" of wound repair by Winter and Hinman. Compared with traditional medical dressings (such as absorbent cotton gauze), modern medical biological dressings have the advantages of accelerating wound healing It has the characteristics of healing, avoiding wound adhesion, promoting tissue repair, antibacterial and anti-inflammatory. In the treatment of burns, the use of antibacterial dressings containing antibacterial drugs is still one of the impo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/18A61L15/44C08F16/06C08F8/28C08K9/12
Inventor 魏坤曾晓峰
Owner SOUTH CHINA UNIV OF TECH
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