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Bacteriostatic component extracted from ageratum conyzoides and extraction method thereof

An extraction method and ethanol extraction technology, which is applied in the field of phytochemistry, can solve the problems that affect the in-depth research of red thistle, the lack of antibacterial active ingredients of red thistle, and the weak research

Inactive Publication Date: 2010-12-08
福建省医学科学研究所
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Problems solved by technology

However, due to the weak basic research of its medicinal materials, there is no research report on the active active ingredients of thistle, let alone the report on the antibacterial active ingredients of thistle; the quality control standards of medicinal materials only include microscopic and physical and chemical identification, which is not enough to control the The quality of thistle also affects the in-depth study of Shenghong thistle and its preparation

Method used

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  • Bacteriostatic component extracted from ageratum conyzoides and extraction method thereof
  • Bacteriostatic component extracted from ageratum conyzoides and extraction method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Embodiment 1 A kind of antibacterial composition extracted from the red thistle

[0017] The red thistle medicinal material is dried and pulverized, and extracted completely with 80% ethanol, and the ethanol is recovered to obtain the red thistle extract, which is added to the extract with appropriate amount of water, extracted with petroleum ether at 60-90°C, and the remaining medicinal solution is re- Extract with ethyl acetate, concentrate the ethyl acetate extract into extractum, use chloroform-methanol (10:1~1:10) repeatedly column chromatography, separate and obtain compound I, through infrared spectrum, ultraviolet spectrum, It was identified as isorhamnetin-3-O-glucoside by mass spectrum, carbon nuclear magnetic resonance spectrum and hydrogen spectrum.

Embodiment 2

[0018] Embodiment 2 A kind of extraction method of antibacterial component of red thistle

[0019] The red thistle medicinal material is dried and pulverized, and extracted completely with 80% ethanol, and the ethanol is recovered to obtain the red thistle extract, which is added to the extract with appropriate amount of water, extracted with petroleum ether at 60-90°C, and the remaining medicinal solution is re- Extract with ethyl acetate, concentrate the ethyl acetate extract into extractum, use chloroform-methanol (10:1~1:10) repeatedly column chromatography, separate and obtain compound I, through infrared spectrum, ultraviolet spectrum, It was identified as isorhamnetin-3-O-glucoside by mass spectrum, carbon nuclear magnetic resonance spectrum and hydrogen spectrum.

Embodiment 3

[0020] Embodiment 3 Determination of the antibacterial component structure of the red thistle

[0021] The conventional identification methods of infrared spectrum, ultraviolet spectrum, mass spectrometry, carbon nuclear magnetic resonance spectrum and hydrogen spectrum were used to determine the structure of the antibacterial components of thistle. As a result, the compound was determined to be isorhamnetin-3-O-glucoside.

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Abstract

The invention discloses a bacteriostatic effective component isorhamcomin-3-O-glucoside of ageratum conyzoides and an extraction method thereof. The isorhamcomin-3-O-glucoside belongs to flavonoid glycoside compounds, has the bacteriostatic function and can be used as a contrast substance for measuring the content of the ageratum conyzoides. The invention lays the foundation for developing a novel product of an ageratum conyzoides preparation aiming at improving the quality control standard of the medicinal material of the ageratum conyzoides.

Description

technical field [0001] The invention relates to the technical field of phytochemistry, in particular to antibacterial components and an extraction method of the red thistle. Background technique [0002] Traditional Chinese medicine has a long history and is a precious wealth of traditional Chinese culture. Although there is no written record of modern medical science of bacterial infection and anti-bacterial infection in traditional Chinese medicine, the treatment methods for cold, heat (fire), dampness, poison, and pestilence have actually included bacterial infection and antibacterial content. Infectious diseases are considered by traditional Chinese medicine to be caused by the deficiency of the body's righteous energy and the internal invasion of heat and toxins. The anti-infective effect of traditional Chinese medicine is different from the single anti-infective effect of western medicine. It has a comprehensive effect in many aspects, that is, it produces a variety o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P31/04
Inventor 刘洪旭林文津
Owner 福建省医学科学研究所
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