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Application of lamiophlomis rotate total glycosides to preparing medicines

A unique and total glycoside technology is applied in the field of unique total glycosides to prepare medicines for the prevention and/or treatment of Alzheimer's disease, which can solve problems such as unseen patent applications and research reports, achieve effective curative effect, easy industrialization, Easy-to-use effects

Active Publication Date: 2010-12-08
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no relevant patent applications and research reports on the use of unicorn for neuroprotection or for the treatment of diseases such as senile dementia.

Method used

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  • Application of lamiophlomis rotate total glycosides to preparing medicines
  • Application of lamiophlomis rotate total glycosides to preparing medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take 10 kg of unique medicinal material, extract three times with 10 times the weight of 50% (volume / volume) ethanol aqueous solution, each time for 1 hour. Collect the extract, recover the ethanol under reduced pressure until there is no alcohol smell, concentrate to an appropriate volume, and place it at room temperature. Centrifuge, the supernatant passes through HPD-300 type macroporous adsorption resin, first washes with water to colorless, removes the impurity soluble in polar solvent, abandons, and then uses 50% (volume / volume / volume) ethanol aqueous solution, collect the ethanol eluate, and dry the eluate after recovering ethanol under reduced pressure to obtain the total glucosides. Based on the total weight of the total glucosides of Solimonas glycosides, the total iridoid glycosides content is 19.3% (weight), the total phenylethanol glycosides content is 27.1% (weight), and the total flavone content is 13.8% (weight).

Embodiment 2

[0036]Take 10kg of unique medicinal material, extract by percolation with 80% (volume / volume) ethanol aqueous solution, the collected percolation liquid is 25 times the volume, recover the ethanol under reduced pressure until it has no alcohol smell, concentrate to an appropriate volume, and place it at room temperature. After centrifugation, the supernatant was passed through HPD-300 macroporous adsorption resin, eluted successively with water and 10% (volume / volume) ethanol aqueous solution until colorless, removed impurities soluble in polar solvents, discarded, and then washed with 3BV 70% (volume / volume) ethanol aqueous solution for elution, collect the ethanol eluate, and dry the eluate after recovering ethanol under reduced pressure to obtain the total glucosides. Based on the total weight of the total glucosides of Solimonas glycosides, the content of total iridoid glycosides is 7.2% (weight), the content of total phenylethanol glycosides is 35.7% (weight), and the cont...

Embodiment 3

[0038] Take 10kg of unique medicinal material, extract with 10 times the weight of water three times, each time for 1 hour, collect the extract, concentrate to an appropriate volume, and place it at room temperature. After centrifugation, the supernatant was passed through HPD-100 type macroporous adsorption resin, firstly eluted with water until colorless, removed impurities soluble in polar solvents, discarded, then eluted with 8BV35% (volume / volume) ethanol aqueous solution, collected The ethanol eluate is dried under reduced pressure after recovering ethanol to obtain the total glucosides of uniquam. Based on the total weight of the total glucosides of Solimonas glycosides, the total iridoid glycosides content is 17.2% (weight), the total phenylethanol glycosides content is 31.6% (weight), and the total flavone content is 8.3% (weight).

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PUM

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Abstract

The invention provides the application of lamiophlomis rotate total glycosides to preparing medicines, i.e. the application of lamiophlomis rotate total glycosides to preparing medicines for preventing and / or treating senile dementia. Shown by pharmacodynamic experimental results, the lamiophlomis rotate total glycosides have obvious memory improvement effect on mouse memory acquisition impairment caused by scopolamine, have obvious effect on improving the learning and memory functions of mice with the learning dysmnesia caused by cerebral ischemia reperfusion and can be clinically used for resisting aging and preventing and / or treating the senile dementia. The medicines of the invention has easily obtained raw materials, are easy to be industrialized, can be made into various preparations according to needs to provide clinical use with modern Chinese medicines with more convenient use, better curative effect, more controllable quality, and bring patients with more benefits so as to generate gigantic social benefits.

Description

technical field [0001] The invention relates to the use of a Tibetan medicine extract in the preparation of a drug for preventing and / or treating senile dementia, in particular to the use of total glycosides in the preparation of a drug for preventing and / or treating senile dementia. Background technique [0002] Alzheimer's disease is a progressive cognitive and memory loss disease, which can be roughly divided into Alzheimer's disease (Alzheimer's disease, AD), vascular dementia (VD) and the mixed type. With the development of society, the speed of population aging is accelerating. According to statistics, more than 20% of the population over the age of 80 in Europe, Japan and the United States suffer from the disease. Worldwide, more than 50 million people over the age of 65 live with some form of dementia. It is estimated that there are about 6 million patients with senile dementia (mainly including senile dementia, other vascular dementia, mixed dementia, and senile d...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P25/28
Inventor 张铁军许浚岳南刘婕只德广
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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