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Process for producing heparin sodium

A production process and heparin sodium technology, applied in the field of pharmaceutical preparation, can solve the problems of polluting the environment, wasting fat intestine residues, etc., and achieve the effects of reducing production costs, increasing added value, and simple resin regeneration

Inactive Publication Date: 2010-11-24
HANGZHOU LONGYANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the above-mentioned shortcomings in the prior art, the present invention finds another way, using the discarded pig intestine skin after removing the mucous membrane as raw material, aiming to provide a new production process of heparin sodium to solve the problem of a large amount of waste The environmental pollution and other problems of fat intestine dregs (mainly intestine skin) will further increase the added value of pig small intestine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The production technique of the heparin sodium of this implementation is as follows:

[0038] (1) Production process of intestinal skin pretreatment process:

[0039] Take the pig small intestine skin from which the mucous membrane has been removed, add water and pulverize it to make a paste, then add 1 times the weight of the intestinal skin with special salt for the casing for pickling, and pickle for one day to obtain the intestinal skin slurry.

[0040] (2) Production process of adsorption process:

[0041] The sausage slurry was filtered with a 60-mesh resin bag before entering the reaction tank, and then diluted with water to a salinity of about 4 degrees, and the pH value was adjusted to neutrality with flake alkali, and then 4 kg of resin was added per 1000L of the sausage slurry, Add Rohm and Haas FPA98 resin, and after stirring and adsorbing for 6 hours, collect the resin,

[0042] (3) The production process of washing and elution process:

[0043] The coll...

Embodiment 2

[0052] The production technique of the heparin sodium of this implementation is as follows:

[0053] (1) Production process of intestinal skin pretreatment process:

[0054] Take the pig small intestine skin from which the mucous membrane has been removed, add water and pulverize it to make a paste, then add 1 times the weight of the intestinal skin with special salt for the casing for pickling, and pickle for one day to obtain the intestinal skin slurry.

[0055] (2) Production process of adsorption process:

[0056] The sausage slurry was filtered with an 80-mesh resin bag before entering the reaction tank, then diluted with water to a salinity of about 5 degrees, and the pH value was adjusted to neutrality with flakes of caustic soda. Add Rohm and Haas FPA98 resin, and after stirring and adsorbing for 6 hours, collect the resin,

[0057] (3) The production process of washing and elution process:

[0058] The collected resin was rinsed repeatedly with tap water and then r...

Embodiment 3

[0067] The production technique of the heparin sodium of this implementation is as follows:

[0068] (1) Production process of intestinal skin pretreatment process:

[0069] Take the pig small intestine skin from which the mucous membrane has been removed, add water and pulverize it to make a paste, then add 1 times the weight of the intestinal skin with special salt for the casing for pickling, and pickle for one day to obtain the intestinal skin slurry.

[0070] (2) Production process of adsorption process:

[0071] Before entering the reaction tank, the sausage slurry was filtered with a 60-mesh resin bag, and then diluted with water to a salinity of about 5 degrees, and the pH value was adjusted to neutrality with flakes of caustic soda. Rohm and Haas FPA98 resin, after stirring and adsorbing for 8 hours, collect the resin,

[0072] (3) The production process of washing and elution process:

[0073] The collected resin was rinsed repeatedly with tap water and then rinse...

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Abstract

The invention belongs to the field of preparation for medicaments, and in particular relates to a process for producing heparin sodium. In the process, the skin of small intestines of a pig from which mucosae is removed serves as a raw material, and the heparin sodium product is obtained by preprocessing, adsorbing, washing, eluting, precipitating and drying sequentially, wherein in the preprocessing step, the skin of the small intestines is crushed into paste, and then salt special for sausage casing is added into the paste for pickling; and in the adsorbing step, acrylic acid strongly basic anion exchange resin, namely rohm and haas FPA98 resin is adopted. The production process can effectively solve the problems of environmental pollution and the like caused by a large amount of waste intestine residue of the pig (the skin of the small intestines primarily), further increases the added value of the small intestines of the pig, and reduces the production cost; and the purity of the product is over 120 titers / mg.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparation, and in particular relates to a production process of environmentally friendly heparin sodium with high yield and high titer. Background technique [0002] Heparin sodium, Latin name Heparin Sodium, heparin sodium is a mucopolysaccharide sulfate anticoagulant. In recent years, studies have shown that heparin sodium also has a lipid-lowering effect. At present, the methods for producing heparin sodium in China are mainly salt hydrolysis and acid hydrolysis, such as the Chinese invention applications with publication numbers of CN101735340A, CN101649008A, CN101519459A, etc. Both methods use porcine intestinal mucosa as raw material, under alkaline conditions Through salt hydrolysis and enzymolysis, after removing part of the protein, it is eluted by trimethylamine quaternary ammonium strong alkaline cation exchange resin adsorbent, and ethanol precipitation is added to the eluate to obtain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10
Inventor 花瑞华潘为群潘为中潘红苏吴鹏飞
Owner HANGZHOU LONGYANG BIOTECH
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