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Nuezhenoside-rhoifolin-hyperin composite and application in medicinal preparation thereof

A technology of rhoside and hyperoside, which is applied in the field of privetin, rhoside, hyperoside composition and its preparation of medicines, can solve problems such as undiscovered, and achieve inhibition of replication, prevention and treatment Influenza and its complications, effects of overcoming side effects

Active Publication Date: 2010-11-24
JIANGXI SHANXIANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been found that the round leaves of Shanxiang and its privetin, rhodorin and hyperin, Ligustrum lucidum and its privet, citrus red and its contained rhodoside, perforatin Peach and its hyperoside have the effect of inhibiting influenza virus infection and replication, and no effect of inhibiting neuraminidase has been found

Method used

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  • Nuezhenoside-rhoifolin-hyperin composite and application in medicinal preparation thereof
  • Nuezhenoside-rhoifolin-hyperin composite and application in medicinal preparation thereof
  • Nuezhenoside-rhoifolin-hyperin composite and application in medicinal preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The composition of lutein, anacardin, and hyperoside provided by the present invention, the molecular formula of the lutein: C 33 H 40 O 18 , Molecular weight: 724.2, the structural formula of the ligustin is as follows:

[0033]

[0034] The molecular formula of anacardin: C 27 H 30 O 14 , Molecular weight: 578.52, and the structural formula of anacardin is as follows:

[0035]

[0036] The molecular formula of hyperoside: C 21 H 20 O 12 , Molecular weight: 464.38, the structural formula of hyperoside is as follows:

[0037]

[0038] Take 1000g of the leaves of Shanxiangyuan, add 12 times the amount of 70% ethanol to reflux extraction for 1.5 hours, filter, and add 10 times the amount of 70% ethanol to the filter residue for reflux extraction for 1.5 hours, filter, combine the two extracts, recover the ethanol, the aqueous solution has passed through The processed D101 macroporous resin column was eluted with water, 10% ethanol, 45% ethanol, 1% sodium hydroxide solution, and ...

Embodiment 2

[0041] Take 1000g of Ligustrum lucidum, add 10 times the amount of 65% ethanol to reflux extraction for 2 hours, filter, add 8 times the amount of 65% ethanol to the filter residue and reflux extraction for 1.5 hours, filter, combine the two extracts, recover the ethanol, and the aqueous solution has passed through The processed D101 macroporous resin column is eluted with water, 8% ethanol, 40% ethanol, 1% sodium hydroxide solution, and the 40% ethanol eluted fraction is collected, concentrated under reduced pressure, and dried to obtain more than 30% lutein The mixed total glycosides were separated by silica gel column chromatography and Sephadex LH-20 column chromatography, combined the fractions of Ligustrum lucidum, and crystallized to obtain the pure Ligustrum lucidum (19.2g, purity: 98.6%). UV, IR, ESI-MS, 1 H-NMR, 13 C-NMR comparison confirmed the structure of Ligustrum.

Embodiment 3

[0043] Take 1000g of orange red, add 10 times the amount of 65% ethanol and reflux for 2 hours, filter, add 8 times the amount of 65% ethanol to the filter residue and reflux for 1.5 hours, filter, combine the two extracts, recover the ethanol, and the aqueous solution has been processed A good D101 macroporous resin column is eluted with water, 10% ethanol, 45% ethanol, 1% sodium hydroxide solution, and the 45% ethanol eluted fraction is collected, concentrated under reduced pressure, and dried to obtain more than 30% anacardin The mixed total glycosides were separated by silica gel column chromatography and Sephadex LH-20 column chromatography, combined with the fractions of anacardin and crystallized to obtain the pure product of anacardin (4.6g, purity: 98.5%), which was compared with the standard UV, IR, ESI-MS, 1 H-NMR, 13 C-NMR comparison confirmed the structure of anacardin.

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Abstract

The invention relates to a nuezhenoside-rhoifolin-hyperin composite, in particular to a composite which is prepared from the following components by weight percent: 80%-40% of nuezhenoside, 5%-45% of rhoifolin and 1%-40% of hyperin. The composite can be used as neuraminidase inhibitor in the prevention and treatment of influenza and be used to prepare pharmaceutically acceptable dosage forms.

Description

Technical field [0001] The present invention relates to a composition of lutein, anacardin, and hyperin, and uses for preparing medicines. Background technique [0002] At present, influenza viruses are becoming more and more serious, and influenza viruses are closely related to respiratory diseases and systemic diseases caused by them. my country is one of the countries with a high incidence of influenza. Not only is there a large population, but also living habits are conducive to the transmission of influenza viruses. The average number of incidences ranged from 0.3 to 0.7, and for key populations reached 2 to 4 times. Influenza poses a serious threat to humans, especially the newly emerging influenza viruses, which not only cause secondary infections of other microorganisms, but also directly lead to organ destruction and allergic reactions leading to death. However, there are currently no effective methods and treatments for the treatment of influenza virus and its diseases ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/16A61P13/12A61P1/00A61P11/00C07H17/07C07H1/08
CPCA61K47/18A61K31/7048A61K9/0095A61K2236/30A61K9/00A61K31/352A61K45/06A61K36/185A61P1/00A61P11/00A61P13/12A61P31/16A61K2300/00
Inventor 杨小玲李志勇叶劲英谢宁吕武清刘地发程帆蔡永红
Owner JIANGXI SHANXIANG PHARMA
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