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Semen cuscutae extract as well as preparation method and semen cuscutae formula granules thereof

A technology of formula granules and dodder, which is applied in the direction of pharmaceutical formula, plant raw materials, medical preparations containing active ingredients, etc., can solve the problems of different organizational structures of medicinal materials, inconsistent product quality, hindering the dissolution of active ingredients, etc., and is suitable for large-scale production , Improve the extraction rate, solve the effect of low extraction rate

Active Publication Date: 2014-07-23
GUANGDONG SECOND PROVINCIAL TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the extraction of medicinal materials of traditional Chinese medicine formula granules is water extraction, or water extraction after extraction of volatile oil. However, due to the different organizational structures of medicinal materials, different manufacturers use different water extraction methods, which eventually lead to inconsistent product quality and differences in drug efficacy.
[0005] At present, the preparation process of dodder formula granules is made by traditional water extraction. After adding water to dodder, a large amount of viscous substances will be produced on the surface of the seed coat, which will hinder the dissolution of active ingredients during industrial extraction. As a result, each gram of dodder formula granules Low content of hyperoside in

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of the dodder extract in this implementation is as follows:

[0038] Take 1000g of dodder medicinal material, add 3000ml of water with glacial acetic acid to adjust the pH value to 3.5 and 10g of cellulase in sequence, heat to 50°C and keep it warm for enzymolysis for 2 hours, then add water to extract twice, add 10 times the volume of medicinal material for the first time water, extract for 2 hours, add water with 8 times the volume of medicinal materials for the second time, extract for 1.5 hours, filter, extract under reduced pressure and concentrate to a relative density of 1.05-1.10 (60°C), spray dry (inlet air temperature: 185 -195°C, air temperature: 75-85°C) to obtain a dry extract, that is, Cuscuta seed extract. The content of hyperin per gram of extract is 10.53mg, and the content of total flavonoids is 98.10mg.

[0039] The preparation method of Cuscuta formula granules: take the dry extract, add appropriate amount of maltodextrin, mix ...

Embodiment 2

[0041] The preparation method of the dodder extract in this implementation is as follows:

[0042] Take 1000g of dodder medicinal material, add 2000ml of water with glacial acetic acid to adjust the pH value to 3 and 5g of cellulase in sequence, heat to 45°C and keep it warm for enzymolysis for 3 hours, then add water to extract twice, add 10 times the volume of medicinal material for the first time water, extract for 2 hours, add water with 8 times the volume of medicinal materials for the second time, extract for 1.5 hours, filter, extract under reduced pressure and concentrate to a relative density of 1.05-1.10 (60°C), spray dry (inlet air temperature: 185 ~195°C, outlet air temperature: 75-85°C) to obtain a dry extract, that is, Cuscuta seed extract. The content of hyperin per gram of extract is 8.43mg, and the content of total flavonoids is 75.69mg.

[0043] The preparation method of Cuscuta formula granules: take the dry extract, add appropriate amount of maltodextrin, m...

Embodiment 3

[0045] The preparation method of the dodder extract in this implementation is as follows:

[0046] Take 1000g of dodder medicinal material, add 4000ml of water adjusted to pH 4 with glacial acetic acid and 15g of cellulase in turn, heat to 55°C and keep it warm for enzymolysis for 1 hour, add water to extract twice, add 10 times the volume of medicinal material for the first time water, extract for 2 hours, add water with 8 times the volume of medicinal materials for the second time, extract for 1.5 hours, filter, extract under reduced pressure and concentrate to a relative density of 1.05-1.10 (60°C), spray dry (inlet air temperature: 185 ~195°C, outlet air temperature: 75-85°C) to obtain dry extract, that is, Cuscuta seed extract. The content of hyperin per gram of extract is 10.04mg, and the content of total flavonoids is 93.73mg.

[0047] The preparation method of Cuscuta formula granules: take the dry extract, add appropriate amount of maltodextrin, mix evenly, dry granulat...

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Abstract

The invention discloses semen cuscutae extract as well as a preparation method and semen cuscutae formula granules thereof. The preparation method of the semen cuscutae extract comprises the following steps of: preparing semen cuscutae, adding water with pH regulated to 3-4 by using glacial acetic acid, adding 0.5wt%-1.5wt% (based on weight of the semen cuscutae) of cellulose and / or pectinase to carry out enzymolysis, extracting with water and filtering to obtain filtrate; concentrating the filtrate under reduced pressure until clear paste is obtained, and drying. A great deal of experiments and researches of the inventor proves that the preparation method disclosed by the invention has the advantages that the enzymolysis technology is adopted to damage seed coat structure of the semen cuscutae and lower viscidity of seed coat surface after water is added to the semen cuscutae; the optimal parameters in enzymolysis and extraction processes are determined, so that extraction rate of hyperoside and total flavonoids is remarkably improved, and therefore, a problem that extraction rate of active ingredients of the semen cuscutae is low is solved. And the method is simple and easy to operate, and suitable for large-scale production.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a dodder extract, a preparation method thereof and dodder formula granules. Background technique [0002] Cuscuta is the dry mature seed of Cuscuta australis R.Br. or Cuscuta chinensis Lam. Nature and flavor are pungent, sweet, flat. Return liver, kidney, spleen channel. It has the effects of nourishing liver and kidney, strengthening essence and reducing urination, preventing miscarriage, improving eyesight and stopping diarrhea. For liver and kidney deficiency, soreness of the waist and knees, impotence and nocturnal emission, enuresis and frequent urination, kidney deficiency and fetal leakage, restless fetal movement, dizziness and tinnitus, spleen and kidney deficiency and diarrhea. [0003] Cuscuta total flavonoids are the main active ingredients of Cuscuta medicinal material, with a content of about 3.0%. The main flavonoids are kaempferol, quercetin, hypero...

Claims

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Application Information

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IPC IPC(8): A61K36/39A61K9/16A61K131/00
Inventor 涂瑶生王洛临孙冬梅施之琪李智勇徐文杰陈雪婷周蓉谢媛陈朋
Owner GUANGDONG SECOND PROVINCIAL TRADITIONAL CHINESE MEDICINE HOSPITAL
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