Novel application of Java brucea fruit oil emulsion injection to anticancer aspect

Abstract

The invention provides novel application of Java brucea fruit oil emulsion injection to the anticancer aspect, in particular to novel application to the anti-leukemia aspect. The invention respectively uses humanized leukemia U937, NB4 and HL-60 cell strains and humanized prostatic carcinoma Du145 cell strains as target cells, and studies the inhabiting effect of the Java brucea fruit oil emulsion injection on the blood system tumor and the urogenital system tumor. The invention discovers that the Java brucea fruit oil emulsion injection has the inhabiting effect on the humanized leukemia HL-60, NB4 and U937cell strains and the humanized prostatic carcinoma Du145 cell strains for the first time, and the inhabiting effect is improved along with the gradual increase of the dosage. In addition, the Java brucea fruit oil emulsion injection can also induce the apoptosis of the humanized leukemia cells, and also has the apoptosis induction effect on the primary dissociated leukemia cells. In addition, the bruceolic oil emulsion injection liquid has low cell toxic effect on peripheral blood lymphocytes of normal persons. The results show that the Java brucea fruit oil emulsion injection has certain potential in the aspect of leukemia treatment, and can provide high-efficiency and low-toxicity medicine for the leukemia treatment.

Description

Technical field [0001] The invention relates to a new use of Brucea javanica oil emulsion injection in anti-cancer, in particular to its use in anti-blood system tumors, urogenital system tumors, especially anti-human leukemia. Background technique [0002] Brucea javanica oil is derived from the mature fruit of Brucea javanica (L) Merr, an evergreen shrub of the bitter wood family or a small tree Brucea javanica (L) Merr. Its anti-cancer active ingredient is the fatty acid of Brucea javanica oil, of which oleic acid accounts for 92.1%. As early as the 1950s, there were reports showing that Brucea Javanica oil has a certain effect on external ear canal papilloma and laryngeal papilloma. In the 1970s, Brucea Javanica injection and Brucea javanica oil intravenous emulsion were found to have good effects on cervical cancer and gastrointestinal cancer. . At present, Brucea javanica oil emulsion injection is mainly used clinically, which is mainly used to treat lung cancer, lung canc...

AI Technical Summary

Problems solved by technology

[0005] There is no report on the use of Brucea javanica oil emulsion injectio

Images