Treatment of pulmonary disorders with aerosolized medicaments such as vancomycin
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A vancomycin, aerosolization technology, which can be used in therapeutic nebulizers, drug combinations, drug delivery, etc., and can solve problems such as harmful health effects
Inactive Publication Date: 2010-10-27
NOVARTIS AG
View PDF31 Cites 10 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
This can ultimately allow individuals in the vicinity of the patient to passively administer the drug, exposing them to the risk of adverse health effects
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0097] As noted above, conventional nebulizer-ventilator systems have low drug delivery efficiencies (eg, less than 20%). Embodiments of the invention include methods and systems that increase delivery efficiency to, for example, at least 25%, or at least 30%, or at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, or more. The increased efficiency in delivering aerosolized drugs may be due in part to one or more features that may be applied in embodiments of the invention. These features include synchronizing the generation of aerosol with the inhalation phase of the ventilator cycle (eg, staged delivery). These features may also include supplying air (eg, "air flow") following the generation of the aerosol, which can clean the endotracheal tube and reduce the amount of drug exhaled by the patient. These features may further include a hub connecting the aerosol generating unit directly to an endotracheal tube connected to the patient. Other features include...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
surface tension
aaaaa
aaaaa
diameter
aaaaa
aaaaa
elastic modulus
aaaaa
aaaaa
Login to view more
Abstract
A method of administering an aerosolized anti-infective, such as a glycopeptide, to the respiratory system of a patient. A ratio of an amount of the glycopeptide, such as vancomycin, delivered to the pulmonary system of the patient in a 24 hour period to a minimum inhibitory amount for the target organ for the same period is about 2 or more. A system to introduce aerosolized medicament to a patient may include a humidifier coupled to an inspiratory limb of a ventilator circuit wye, where the humidifier supplies heated and humidified air to the patient, and an endotracheal tube having a proximal end coupled to a distal end of the ventilator circuit wye. The system may also include a nebulizer coupled to the endotracheal tube, where the nebulizer generates the aerosolized medicament.
Description
[0001] Cross References to Related Applications [0002] This application claims priority and is a continuation-in-part of US Patent Application US 60 / 975,094, filed September 25, 2007. [0003] This application claims priority and is a continuation-in-part of US patent application US 11 / 654,212, filed January 16, 2007. US 11 / 654,212 is a continuation-in-part of US patent application US 11 / 090,328 filed March 24, 2005. US 11 / 090,328 is a continuation-in-part of US 10 / 345,875 filed January 15, 2003. [0004] This application additionally claims priority and is a continuation-in-part of US Patent Application US 10 / 284,068, filed October 30, 2002. US 10 / 284,068 claims the benefit of US 60 / 344,484, filed November 1, 2001, and US 60 / 381,830, filed May 20, 2002. The entire contents of all the above-mentioned documents are incorporated herein. [0005] This application is also related to US patent applications US 2002-0134375, US 2002-0134374, US patents US 6,948,491, US 6,615,824,...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.