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Curcumin self-microemulsion and preparation method thereof

A technology of curcumin and self-microemulsion, which is applied in the field of self-microemulsion, can solve the problems of low bioavailability, unstable aqueous solution, and low blood drug concentration, and achieve the goal of improving membrane permeability, stability, and absorption in the body Effect

Inactive Publication Date: 2010-10-27
SHANDONG LUNUO ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of curcuminoids in water is small, and its aqueous solution is unstable under neutral and alkaline conditions.
After oral administration of curcuminoids, the plasma concentration is low and the bioavailability is low

Method used

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  • Curcumin self-microemulsion and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0022] Curcumin self-microemulsifying, made from the following components by weight:

[0023] Curcumin 3 grams, Labrafac 18 grams, glyceryl caprylate 8 grams, sodium octadecyl sulfate 50 grams, ethanol 21 grams.

Embodiment 2

[0025] Demethoxycurcumin self-microemulsion, made from the following components by weight:

[0026] 0.05 grams of demethoxy curcumin, 35 grams of isopropyl myristate, 24.95 grams of lecithin, and 40 grams of isopropanol.

Embodiment 3

[0028] The preparation method of curcumin self-microemulsion adopts the following steps:

[0029] Weigh 80 grams of Cremophor RH40, 9 grams of Transcutol and mix evenly, add 10 grams of isopropyl myristate, mix for 35 minutes, then add 1 gram of curcumin, stir for 24 hours to fully dissolve, centrifuge to obtain curcumin self-micro milk, encapsulated in soft capsules.

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Abstract

The invention discloses a self-microemulsion, in particular to a curcumin self-microemulsion and a preparation method thereof. The curcumin self-microemulsion is characterized by the following components by weight percent: 0.05%-10% of curcumin, 1%-35% of oil phase, 20%-80% of surfactant, and 2%-40% of cosurfactant. The curcumin self-microemulsion and the preparation method thereof has the benefits that: a curcumin self-microemulsion release system increases the solubility of drugs, protects the drugs dissolved in oil drops, and improves the stability in a body; and the surfactant can change the flowability of cell membranes, improve membrane permeability of the drugs, enhance the absorption of the drugs in the body and increase the relative bioavailability of oral drugs.

Description

(1) Technical field [0001] The invention relates to a self-microemulsion, in particular to a curcuminoid self-microemulsion and a preparation method thereof. (2) Background technology [0002] Curcumin is an effective part isolated from the underground rhizomes of turmeric (curcuma longa L.), turmeric (curcuma wenyujin Y.H.Chen et C.Ling) and curcuma (Curcuma phaeocaulis Val.). It is a kind of natural linear diaryl heptanone compound, from which three active ingredients can be separated: curcumin, demethoxycurcumin and bisdemethoxycurcumin. Curcuminoids are often used as pigments and flavoring additives of various foods, and have a wide range of biological activities such as anti-tumor, hypolipidemic, anti-atherosclerosis, anti-inflammation, and anti-oxidation. However, the solubility of curcuminoids in water is small, and their aqueous solutions are unstable under neutral and alkaline conditions. After oral administration of curcuminoids, the plasma concentration is low a...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/107A61K31/12A61P35/00A61P3/06A61P9/10A61P29/00A61P39/06
Inventor 姜运华姜知喜尚永涛
Owner SHANDONG LUNUO ANIMAL PHARMA
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