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Improved biodegradable porous scaffold particle for injection and preparation method thereof

A technology for biodegradability and injection, applied in the field of porous biodegradable scaffold particles for injection and its preparation, can solve the problems of flow, use restriction, lack of adaptability to organisms, etc., and achieve the effect of a good growth environment

Inactive Publication Date: 2010-09-22
四川合泰新光医药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The problem that has arisen in the recent manufacture of artificial organs is that the use of these materials is extremely limited due to the lack of adaptability to the organism and the lack of biological functionality when replacing specific parts of damaged organs or tissues
[0017] When the current synthetic polymers and tissue regeneration substances composed of other polymers are injected into the skin, there is a phenomenon that they flow at the injection site, which is also a problem that must be solved.

Method used

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  • Improved biodegradable porous scaffold particle for injection and preparation method thereof
  • Improved biodegradable porous scaffold particle for injection and preparation method thereof
  • Improved biodegradable porous scaffold particle for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] An improved porous biodegradable scaffold particle for injection, which is mainly composed of biodegradable polymers, wherein the biodegradable polymers are polylactic acid PLA with an average molecular weight range of 150,000.

[0040] A preparation method of an improved porous biodegradable scaffold particle for injection, which comprises the following steps:

[0041] (1) The biodegradable polymer is dissolved in the methylene chloride organic solvent to form an organic solution, the weight percentage of the biodegradable polymer dissolved and the organic solvent is 1.67:98.33, then the organic solution is mixed with water, the organic solution and The weight percentage of water is 30:70;

[0042] (2) Stir the mixture of the solvent solution and water on a mixer at a speed of 2000 rpm for 40 minutes, and maintain the internal temperature of the mixer at 20° C. to form a softened solution;

[0043] (3) Put the softened solution into a mold made of polytetrafluoroethyl...

Embodiment 2

[0047] An improved porous biodegradable scaffold particle for injection, which is mainly composed of biodegradable polymers, wherein the biodegradable polymers are polylactic acid PLA with an average molecular weight range of 10,000.

[0048] A preparation method of an improved porous biodegradable scaffold particle for injection, which comprises the following steps:

[0049] (1) The biodegradable polymer is dissolved in the acetonitrile organic solvent to form an organic solution, the weight percentage of the biodegradable polymer dissolved and the organic solvent is 45:55, then the organic solution is mixed with water, the organic solution and water The weight percentage is 90:10;

[0050] (2) Stir the mixture of the blender solution and water on a blender at a speed of 5000 rpm for 20 minutes, and maintain the internal temperature of the blender at 40° C. to form a softened solution;

[0051] (3) Put the softened solution into a mold made of polytetrafluoroethylene, and fr...

Embodiment 3

[0055] An improved porous biodegradable scaffold particle for injection, which is mainly composed of biodegradable polymers, wherein the biodegradable polymers are polylactic acid PLA with an average molecular weight range of 120,000.

[0056] A preparation method of an improved porous biodegradable scaffold particle for injection, which comprises the following steps:

[0057] (1) The biodegradable polymer is dissolved in the methylene chloride organic solvent to form an organic solution, the weight percentage of the biodegradable polymer dissolved and the organic solvent is 15:85, then the organic solution is mixed with water, the organic solution and The weight percentage of water is 60:40;

[0058] (2) Stir the mixture of the solvent solution and water on a mixer at a speed of 4000 rpm for 30 minutes, and maintain the internal temperature of the mixer at 35° C. to form a softened solution;

[0059] (3) Put the softened solution into a mold made of polytetrafluoroethylene, ...

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Abstract

The invention discloses an improved biodegradable porous scaffold particle for injection and a preparation method thereof. The improved biodegradable porous scaffold particle mainly comprises biodegradable polymers. The preparation method comprises the following steps: dissolving the biodegradable polymers in organic solution; mixing with water and stirring to form softened solution; freezing, drying and foaming the softened solution at the specific temperature to form foaming substances; further crushing the foaming substances by a crusher; mixing the crushed foaming substances with softenersolution; and freezing, drying and sterilizing. The invention has the following beneficial effects: the adopted raw material per se is not harmful to human body, while the endothelial cells and skin tissues of the human body can be easily attached to the raw material, thus providing the good growing environment for the cells and favoring for the growth of the cells; and the porous biodegradable scaffold particle can be naturally decomposed and absorbed in vivo within a certain period of time, thus avoiding the risks of in-vivo accumulation.

Description

technical field [0001] The invention relates to a porous injection biodegradable scaffold particle and a preparation method thereof, in particular to an improved porous injection biodegradable scaffold particle and a preparation method thereof. Background technique [0002] Biodegradable polymer is a kind of material that is easy to attach and grow in various tissues and cells such as epithelial tissue in the human body, and is biodegraded after the growth of cells or tissues, and has the characteristics of being absorbed or eliminated by the human body. Widely used in tissue engineering. [0003] First of all, looking at the development history of medical polymer materials, the first generation of artificial implants such as ceramics, metals, composite materials and polymer materials were used as materials for filling supports. [0004] The second generation uses general industrial materials to replace a part of damaged organs. These materials are inactive and have no effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/24A61L27/22A61L27/18A61L27/56A61L27/58
Inventor 崔明杜彦军
Owner 四川合泰新光医药有限公司
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