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Pachysandra terminalis alkaloid compound for resisting tumor metastasis

An anti-tumor metastasis and alkaloid technology, applied in anti-tumor drugs, steroids, drug combinations, etc.

Inactive Publication Date: 2010-09-08
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no anti-tumor metastasis drug available in the world

Method used

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  • Pachysandra terminalis alkaloid compound for resisting tumor metastasis
  • Pachysandra terminalis alkaloid compound for resisting tumor metastasis
  • Pachysandra terminalis alkaloid compound for resisting tumor metastasis

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Embodiment Construction

[0029] Extraction, Isolation and Structure Identification of Alkaloid Compounds 1-7 from G.

[0030] 1. Extraction and separation of the alkaloid compounds 1-7 of G.

[0031] Take 10 kg of natural dried Herba genus G. pulveris, and then heat and reflux extract with 6 times the amount of 95% ethanol for 3 times, 6 hours each time. The extract was concentrated under reduced pressure to obtain 700 g of extract, which was suspended with water and extracted with petroleum ether, ethyl acetate, and n-butanol respectively to obtain 101 g of petroleum ether extract, 88 g of ethyl acetate extract, and extracted with n-butanol. 360g of the substance and the water layer part of the turpentine grass.

[0032] The petroleum ether extract was chromatographed on a silica gel column and eluted with a gradient of petroleum ether-ethyl acetate-methanol to obtain 22 components (Fre. 1-22). Fractions Fre.8-15 were combined, separated by silica gel column chromatography, dichloromethane-methanol...

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Abstract

the invention relates to a pachysandra terminalis alkaloid compound for resisting tumor metastasis (as shown in the figure), which comprises 9-dimethylamino-4,7-megastigmadien-3-one (1), E-salignone (2), Z-salignone (3), 3beta-(3'alpha-isopropyl)-lactam-5alpha-pregn-4-one (4), pachystermine A (5), 3-spiro-(3'-oxo-isoindole)-5alpha-pregn-20-one (6) and 3beta-(methylsenecioylamino)-5alpha-pregn-20-one(7). The invention has a strong effect on resisting the chemotaxis migration of breast cancer cells, and can be used for preparing medicaments for resisting tumor metastasis.

Description

technical field [0001] The invention relates to an anti-tumor metastases alkaloid compound belonging to the research field of active ingredients of traditional Chinese medicines. Background technique [0002] According to the data released by WHO, in 2005, among the 58 million total deaths in the world, the deaths caused by various tumors accounted for 13%. Tumors have become one of the major diseases that seriously threaten human health today. With the advancement of life sciences and the development of medicine, human beings' understanding of tumors has penetrated to the molecular and cellular level, and various new surgical treatment methods and chemotherapy drugs are constantly coming out. However, according to statistics from the American Institute of Cancer Research, over the past 50 years, cancer treatment has not been fundamentally improved, and cancer mortality remains high. The main reason is tumor metastasis, and there are no effective treatments and drugs for tum...

Claims

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Application Information

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IPC IPC(8): A61K31/13A61K31/57A61K31/58A61P35/04C07C225/14C07J41/00
Inventor 段宏泉翟慧媛唐生安靳美娜李晨阳
Owner TIANJIN MEDICAL UNIV
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