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Preparation method of sucralose

A technology for sucralose and sucralose, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of low yield of sucralose, etc. short time effect

Active Publication Date: 2010-08-25
南通宏信化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage of the above-mentioned single-group protection method is: the acetylation reagent selected in the acylation reaction is usually trimethyl orthoacetate or acetic anhydride, and this type of acetylation reagent leads to a low yield of the final sucralose

Method used

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  • Preparation method of sucralose

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Embodiment 2

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Abstract

The invention discloses a method for preparing sucralose by using a new acetylation reagent, which comprises the following steps: (1) acylation reaction: reacting sucrose with acetylation reagent to produce sucrose-6-acetate; (2) chlorination reaction: carrying out chlorination reaction on the sucrose-6-acetate obtained in the step (1) to obtain sucralose-6-acetate; (3) and deacetylation reaction: carrying out deacetylation reaction on the sucralose-6-acetate obtained in the step (2) to obtain sucralose. The ketene gas used in the acylation reaction is used as the acetylation reagent. The method can effectively increase the sucralose yield, and has the advantages of short reaction time, easy control of reaction temperature, and easy realization of industrial production.

Description

technical field The invention relates to a method for synthesizing sweetener sucralose, and further relates to a method for preparing sucralose by using sucrose and organic reagents as raw materials and adopting a single-group protection method. Background technique Sucralose, chemical name 4,1',6'-trichloro-4,1'6'trideoxygalactose, its sweetness is 600 times that of sucrose, widely used in beverages, chewing gum, bread, jelly and other foods In addition, its application in the field of medicine is also expanding. Using sucrose and organic reagents as raw materials, the method for preparing sucralose by the single-group protection method includes the following three process steps: (1) acylation reaction, first dissolving sucrose in an organic solvent, then adding acetylating reagents for reaction, and reacting After finishing, remove solvent and filter and dry to obtain sucrose-6-acetate; (two) chlorination reaction, the sucrose-6-acetate that first step reaction is obtaine...

Claims

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Application Information

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IPC IPC(8): C07H5/02C07H1/00
Inventor 陈小萍陈颖刘纪才
Owner 南通宏信化工有限公司
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