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Nano-pore tester for rapidly analyzing unimolecule

A rapid analysis, nanopore technology, applied in the direction of analyzing materials, material analysis by electromagnetic means, instruments, etc., to achieve high accuracy and rapid detection results

Inactive Publication Date: 2013-01-30
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is the lack of efficient selection of individual sample molecules

Method used

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  • Nano-pore tester for rapidly analyzing unimolecule
  • Nano-pore tester for rapidly analyzing unimolecule
  • Nano-pore tester for rapidly analyzing unimolecule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] figure 1 The functional block diagram of the nanopore tester system provided by the present invention. Such as figure 1 As shown, it includes five main components: micro-nano hole channel system, signal acquisition system, signal analysis system, sample dynamic detection and control system and computer display system.

[0030] figure 2 It is a schematic diagram of the structure of the micro-nanopore channel system, which can select a single DNA molecule and manipulate its directional movement, including the sample storage pool (1), the sample recovery pool (2), the sample recovery pool (3), the initial injection channel ( 11), sample inlet channel (12), auxiliary sample outlet channel (13), sample outlet channel (14), electrode (4), electrode (5), electrode for selecting a single DNA molecule, and detecting and regulating sample transport state (6), electrode (7), electrode (8), electrode (9), electrode (10) and nanopore (15).

[0031] The micro-nanopore channel sy...

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Abstract

The invention discloses a nano-pore tester capable of rapidly analyzing unimolecule, comprising a sample operation system and a signal processing system, wherein the sample operation system is used for guiding an analyzed sample to stretch out and pass through a nano-pore channel system at a constant speed without entanglement, and comprises a micro nano-pore channel system and a dynamic detection and regulation system; and the signal processing system is composed of a signal acquisition system, a signal analyzing system and a computer display system. The nano-pore tester provided by the invention can be applicable to gene super-fast sequencing, screening, separating and counting biological unimolecule, and screening and analyzing drug molecules at a nanometer order.

Description

technical field [0001] The invention relates to a nanopore tester that can be used for the research of multiple characteristics of a single molecule. The tester can be used for ultra-fast sequencing of genes, screening and separation of biological single molecules (DNA, RNA, protein molecules, etc.) , counting, and can be used for screening and analysis of drug molecules of nanometer size. Background technique [0002] At present, the methods for detecting biological single molecules, especially the commonly used methods for detecting the sequencing of DNA molecules, include the "Sanger method" and "shotgun method", as well as the method invented by Jonathan Rothberg of "454 Life Sciences" and his colleagues - the pyrosequencing method. The basic principles and methods of these sequencing methods are to "segment" the samples first, then "sequence", and finally "splicing". Using these techniques to fully sequence an organism's genes is expensive and time-consuming. [0003]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/416
Inventor 王凯歌白晋涛任兆玉贺庆丽高爱华
Owner NORTHWEST UNIV
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