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Preparation method of modified collagen film

A technology of collagen and hydrolyzed collagen, applied in peptide/protein components, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as skin burns, and achieve the effects of easy absorption, elimination of side effects, and low antigenicity

Inactive Publication Date: 2010-08-11
BEIJING ANQIANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, for the treatment of refractory skin ulcers, severe or deep skin burns, scald medicines, there is no record of relevant content in domestic and foreign literatures

Method used

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  • Preparation method of modified collagen film
  • Preparation method of modified collagen film
  • Preparation method of modified collagen film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Add 100g of endotoxin-free collagen powder into the reactor, and add about 400ml-500ml of deionized water (the purpose of adding deionized water is mainly to make the collagen swell, so just add an appropriate amount, and the following examples will no longer specify The amount of deionized water added, as long as the amount of water is adjusted according to the actual situation when implementing the present invention), after the collagen is swelled for about 30 minutes, and heated to about 65°C during stirring to dissolve, then add 5g of comfrey to extract substance and an appropriate amount (about 10 g in this example) of glycerin (100% glycerol) are fully mixed, and after the mixing is completed, stop stirring and keep warm, and use a 0.25 μm microfiltration membrane (multiple different materials can be used, such as ceramic materials or Microfiltration membranes prepared from cellulose materials can be used) after filtration, vacuum defoaming and subsequent use.

Embodiment 2

[0066] Except that comfrey consumption is 50g, all the other are identical with embodiment 1.

Embodiment 3

[0068] Add 100g of endotoxin-free collagen powder into the reactor, add an appropriate amount of deionized water, swell for an appropriate time at room temperature, add an appropriate amount of comfrey extract as in Example 1, then add 60g of hydrolyzed collagen, and start Stirrer and thermostat switch, the temperature is controlled at about 70°C, so that the hydrolyzed collagen is completely dissolved, left to keep warm, and filtered with a 0.25 μm microfiltration membrane, vacuum degassed for later use.

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PUM

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Abstract

The invention prepares various forms of pharmaceutical compositions by combining de-endotoxin collagen with a lithospermum extract for treating skin lesions or diseases. Moreover, one or more biologically active substances can be added to the compositions for treating skin lesions, such as ulcers, and the like, particularly treating skin ulcers caused by diabetes. The pharmaceutical compositions can be prepared into medical films by using de-endotoxin collagen as a substrate, has the advantages of high mechanical strength, strong toughness, good moisture retention, adhesion and permeability, rapid stimulation of skin regeneration and easy biodegradation without adverse reactions.

Description

Technical field: [0001] The invention belongs to the field of biomedicine, and is prepared into a medicament by combining the traditional Chinese medicine comfrey (the comfrey extract purchased in a pharmacy, i.e. comfrey oil) and collagen to treat skin damage, especially those caused by diabetes. Skin ulcers, and in comfrey extract. Background technique: [0002] The skin is the largest organ of the human being, and it has a strong protective effect against the invasion of foreign organisms. Therefore, when the skin is damaged, it also means that various foreign microorganisms are more likely to enter the body, which poses a great threat to human health. Skin damage includes mechanical physical damage, chemical damage and skin lesions caused by some special diseases. Among them, mechanical and physical injuries, such as stab wounds caused by knife wounds and other sharp objects, etc., chemical injuries are injuries caused by skin contact with corrosive substances, etc. If...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K9/70A61P17/02A61P3/10A61K38/18A61K36/30A61K31/737A61K31/723A61K31/722
Inventor 张志强刘宣亚
Owner BEIJING ANQIANG BIOTECH
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