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Poly-lactic acid fiber loading powder drug and preparation method thereof

A technology of polylactic acid fiber and polylactic acid, which is applied in the field of drug-loaded polylactic acid fiber and its preparation, can solve the problems of insoluble solid powder drugs and achieve the effect of controlled release

Inactive Publication Date: 2012-07-04
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the drugs involved in the above method are either water-soluble or fat-soluble drugs, and do not involve insoluble solid powder drugs.

Method used

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  • Poly-lactic acid fiber loading powder drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Step (1) Prepare 2 milliliters of an aqueous solution of 0.01 g / mL sodium alginate.

[0028] Step (2) Add 0.03 g of talcum powder (powder type drug) to (1), and stir for 5 minutes.

[0029] Step (3) Add 1 g of AOT (surfactant) and 25 mL of dichloromethane to (2), and stir for 5 minutes.

[0030] Step (4) Add 0.05 g of calcium chloride to (3), stir ultrasonically for 15 minutes, and solidify, so that the talcum powder is trapped in the calcium alginate droplet.

[0031] Step (5) Prepare 20 mL of a 0.01 g / mL polylactic acid solution with a molecular weight of 70,000, and the solvent is dichloromethane.

[0032] Step (6) Mix (4) and (5) and stir evenly to obtain an electrospun emulsion.

[0033] In step (7), the electrostatic emulsion electrospinning is performed at a voltage of 10.88KV, an electrode distance of 8cm, and a rate of 0.4mL / h, and the electrospun filaments are collected on tin foil.

[0034] The average diameter of the obtained drug-loaded (talcum powder) p...

Embodiment 2

[0036] Replace "0.01g / mL sodium alginate aqueous solution 8 ml" in (1) with "0.01g / mL sodium alginate aqueous solution 2 ml", replace (2) with "10g Shengjisan" "0.03g of talc", replace "1g of AOT (surfactant) and 25mL of dichloromethane" in (3) with "5g of polyvinylpyrrolidone (PVP) and 100mL of hexafluoroisopropanol", replace with " The calcium chloride of 5g " replaces " the calcium chloride of 0.05g " in (4), replaces " solvent is dichloromethane " in (5) with " solvent is hexafluoroisopropanol ", all the other repeat in the embodiment Steps (1) to (7), the same method is used to obtain drug-loaded (Shengjisan) polylactic acid fibers with a diameter of 0.15-1 μm and a beaded structure with a diameter of 1-10 μm.

Embodiment 3

[0038] Replace "0.03g of talcum powder" in (2) with "20g of zinc carbonate", and repeat (1) to (7) steps in the examples, and obtain drug-loaded (zinc carbonate) polylactic acid fibers in the same way. The diameter is 0.5-1 μm, and the diameter of the beaded structure is 1-10 μm.

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Abstract

The invention relates to a poly-lactic acid fiber loading a powder drug and a preparation method thereof. The components of the poly-lactic acid fiber loading the powder drug comprise: poly-lactic acid as a main body of fiber, calcium alginate and solid powder drug, the fiber has a beaded structure, the diameter of the fiber is 0.15-1.5mum, the diameter of the bead is 1-10mum, and the drug loading rate thereof can be adjusted in the range of 0-100 percent. When the electrostatic spinning technology is used to prepare the poly-lactic acid fiber loading the powder drug, the fiber is collected on a silver paper. The drug loaded poly-lactic acid fiber of the invention has the beaded structure, and the drug is basically stored in the beaded structure; the drug can be gradually released with the degradation of the poly-lactic acid, thereby effectively controlling the release of the drug; by selecting the poly-lactic acid with different molecular weights, the degradation speeds of the drug loaded poly-lactic acid fiber prepared by the invention can be different, and the release speeds of the drug are different.

Description

technical field [0001] The invention relates to a drug-loaded polylactic acid fiber and a preparation method thereof, in particular to a polylactic acid electrospun fiber with a beaded structure loaded with powdered drugs and a preparation method thereof. Background technique [0002] Electrospinning can prepare ultrafine fibers with a diameter of nanometer to submicron. The nonwoven fabric composed of ultrafine fibers has high porosity and specific surface area, and good air permeability, so it is often used for medical purposes. Fabric or non-fabric to accelerate tissue repair regeneration and promote wound healing. [0003] Because electrospinning is a process in which a polymer solution or melt is sprayed under a high-voltage electric field to form nanoscale fibers, the type and molecular weight of the polymer, the concentration and viscosity of the polymer solution, the conductivity of the polymer solution, the solvent, and the applied voltage , solution base speed, et...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F6/92D01F1/10A61L17/12A61K47/34A61K31/337A61K31/7052A61K31/7048A61K33/12A61K33/30A61K31/17A61K31/405A61K38/13A61K31/704A61K31/496A61K31/192A61K31/138A61K31/4184A61K35/36A61K36/282
Inventor 朱以华杨晓玲李翠燕李浩鹏亢海刚
Owner EAST CHINA UNIV OF SCI & TECH
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