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Application of nutritional composition in preparation of medicine for promoting proliferation of liver stem cells

A technology of liver stem cells and nutritional composition, which is applied in the application field of nutritional composition in the preparation of drugs for promoting liver stem cell proliferation, can solve problems such as undocumented, achieve the effect of not producing immune rejection and promoting the proliferation of adult liver stem cells

Active Publication Date: 2012-02-01
珍奥集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the patent application document does not record that the nutritional composition has the effect of promoting the proliferation of liver stem cells

Method used

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  • Application of nutritional composition in preparation of medicine for promoting proliferation of liver stem cells
  • Application of nutritional composition in preparation of medicine for promoting proliferation of liver stem cells
  • Application of nutritional composition in preparation of medicine for promoting proliferation of liver stem cells

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Experimental program
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Effect test

Embodiment Construction

[0012] 1. Establish model, experiment grouping and experiment process

[0013] Establishment of aplastic anemia mouse model: BALB / c mice were used in this experiment. Experimental procedure: Acetylhydrazine 100mg / kg was injected subcutaneously on day 1, X-ray 2.0Gy was irradiated on the next day, cyclophosphamide 80mg / kg was injected intraperitoneally on day 5, and the above steps were repeated on day 15 without radiation treatment. The normal control group was injected with the same amount of normal saline at the corresponding site.

[0014] Experimental grouping: According to the drug dosage of animal pharmacology and the design and analysis of comprehensive experiments, it is divided into: ① normal control group; ② aplastic anemia model group; ③ high dose group, with 1445.55mg / kg. Rats were given intragastric administration; ④ medium dose group, 963.7 mg / kg.d nutritional composition was administered to aplastic mice; ⑤ low dose group, 674.59 mg / kg.d nutritional composition...

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Abstract

The invention discloses the application of a nutritional composition in the preparation of drugs for promoting the proliferation of liver stem cells. While promoting the proliferation of hematopoietic stem cells and the synthesis of hemoglobin, the nutritional composition can also create conditions for awakening dormant adult liver stem cells, thereby promoting Proliferation of adult liver stem cells. It solves various problems existing in the existing orthotopic liver transplantation and donor liver stem cell transplantation, and has the advantages of being effective, safe, simple, economical, and does not produce immune rejection.

Description

Technical field: [0001] The invention relates to the use of a nutritional composition, in particular to the application of a nutritional composition in the preparation of drugs for promoting the proliferation of liver stem cells. Background technique: [0002] Many refractory liver diseases such as chronic hepatitis, liver fibrosis and cirrhosis, portal hypertension, primary liver cancer, hereditary and metabolic liver diseases are thorny problems faced by the whole world. Orthotopic liver transplantation is currently the only effective treatment for end-stage liver failure caused by the above-mentioned reasons. However, due to the extreme shortage of liver donors, the high mortality rate associated with surgery and transplantation itself, the life-long administration of immunosuppressants and the serious or even fatal complications, the widespread clinical application of liver transplantation is greatly limited. [0003] With the continuous development of stem cell biology...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/87A61P1/16A61K33/26A61K33/30A61K33/32A61K31/714A61K31/525A61K31/4415A61K31/519A61K31/375A61K31/355A61K31/715A61K31/685A61K31/7052A61K31/198A61K31/4172
Inventor 吴文国李恕董锋
Owner 珍奥集团股份有限公司
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