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Water-soluble nuclear-shell magneto-optic dual-function nanoparticle and preparation method thereof

A nanoparticle, water-soluble technology, applied in the field of water-soluble core-shell magneto-optical dual-functional nanomaterials and its preparation, can solve the problems of low utilization of cobalt ferrite magnetic nanomaterials, affecting the wide application of nanomaterials, and fluorescence quenching of luminescent materials. , to achieve the effects of easier control of morphology and particle size, good saturation magnetic susceptibility and relaxation ability, and good biocompatibility

Inactive Publication Date: 2010-07-14
SHANGHAI NORMAL UNIVERSITY
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, most of the preparation of magnetic nano-ferrite materials is mainly based on the synthesis of ferric oxide and manganese ferrite. The utilization of cobalt ferrite magnetic nanomaterials is relatively seldom. Most of the existing cobalt ferrite magnetic nanoparticles are oil Solubility, uneven size
Existing methods such as ligand exchange and polymer coating are used to solve the problem of water solubility, but most of the experimental methods are more complicated and costly, and accompanied by agglomeration
Existing methods for preparing magneto-optic dual-functional nanomaterials can easily lead to fluorescence quenching of luminescent materials, so the fluorescence efficiency is not high, which seriously affects the wide application of nanomaterials in the fields of medicine and biology.

Method used

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  • Water-soluble nuclear-shell magneto-optic dual-function nanoparticle and preparation method thereof
  • Water-soluble nuclear-shell magneto-optic dual-function nanoparticle and preparation method thereof
  • Water-soluble nuclear-shell magneto-optic dual-function nanoparticle and preparation method thereof

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Effect test

Embodiment 1

[0036] Embodiment 1: Iron acetylacetonate (Fe(acac) 3 ) preparation

[0037] Weigh 2.705g (10mmol) FeCl 3 ·6H 2 O into a 100mL round bottom flask, add 10mL of water and a stirring magnet. Place the round-bottomed flask on a magnetic stirring heater and stir to make the FeCl 3 ·6H 2 O was completely dissolved (solution was brownish yellow).

[0038] Measure 6.1mL acetylacetone (60mmol) and add in the flask, the solution turns red immediately, stirs for 15 minutes to make it mix with Fe 3+ fully responsive. After the reaction was complete, 3 mL of triethylamine was added. After the iron acetylacetonate crystallizes out, filter it with a Buchner funnel. The obtained iron acetylacetonate was put into a round bottom flask for recrystallization.

[0039] Measure 30mL of water and 70mL of absolute ethanol and mix them in a 100mL volumetric flask to prepare a water-ethanol mixture with a volume ratio of 3:7. Take 15 mL of the above mixed solution into a round bottom flask, s...

Embodiment 2

[0040] Embodiment 2: cobalt acetylacetonate (Co(acac) 2 ) preparation

[0041] The preparation method of this embodiment is the same as that described in Example 1, the difference is that CoCl 2 ·6H 2 O instead of FeCl 3 ·6H 2 O, the volume of acetylacetone was changed from 6.1 mL to 4.1 mL.

Embodiment 3

[0042] Example 3: CoFe 2 o 4 Preparation of nanoparticles

[0043] Take Fe(acac) 3 and Co(acac) 2 A total of 2mmol (of which Fe(acac) 3 The molar ratio to Co(acac) is 2:1), 2g of 1,2-hexadecanediol (7.7mmol) was dissolved in 20mL of phenylene ether, and 2mL of oleic acid and oleylamine (6mmol) were added dropwise. Under the protection of nitrogen, the mixed solution was heated to 100°C for 30min, then heated to 200°C for 1h, then heated to 265°C for 30min, and finally the heat source was removed, and the reaction system was cooled to room temperature. Add excess ethanol to the obtained black solution and centrifuge to obtain black CoFe 2 o 4 Nanoparticle precipitation. Dry the solid obtained by centrifugation in a vacuum oven for 12-24 hours. CoFe 2 o 4 Nanoparticles can be dispersed in non-polar solvents such as n-hexane and n-octane, and have good dispersibility and stability.

[0044] figure 1 This is the TEM image of the cobalt ferrite nanoparticles synthesized...

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Abstract

The invention relates to the technical field of the composite material, and discloses a water-soluble nuclear-shell magneto-optic dual-function nanoparticle. In the structure of the water-soluble nuclear-shell magneto-optic dual-function nanoparticle, magnetic CoFe2O4 is used as a core, amorphous SiO2 is used as a shell, the surface of the shell is connected with an organic light-emitting material dansyl chloride, and the particle size is 25-50nm. The preparation method comprises the following steps: preparing a monodisperse magnetic cobalt ferrite nanoparticle through thermal decomposition, coating silica on the surface of the nanoparticle, carrying out modification of amino on the surface of the silica, and connecting an organic light-emitting material through the amino on the peripheryof the magnetic nanoparticle. The nanoparticle of the invention has a nuclear-shell structure and a uniform particle size, and can be well dispersed in water. Moreover, the nanoparticle of the invention has good water solubility, good magnetic properties, light-emitting effect and good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and relates to a water-soluble core-shell magneto-optical dual-functional nanometer material and a preparation method thereof. Background technique [0002] There are many types of magnetic nanoparticles, and the more common ones are metal alloys, metal oxides, and ferrite series. Among the many magnetic nanoparticles, the ferrite series has been studied the most. Ferrite series magnetic nanoparticles mainly include Fe 3 o 4 , MnFe 2 o 4 , CoFe 2 o 4 , NiFe 2 o 4 Wait. Ferrite magnetic nanoparticles have unique magnetic properties, such as superparamagnetism and high saturation magnetization, and have broad applications in biomedical fields such as targeted drug carriers, magnetic resonance imaging, separation of cells and biomolecules, and immunoassays Therefore, it has attracted people's attention in recent years. [0003] At present, there are many methods for prepar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06H01F1/34
Inventor 吴惠霞郑浩然杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
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