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Rare earth element cerium slow-release artificial tooth root based on nanotube array surface

A nanotube array, artificial tooth root technology, applied in dentistry, dental preparations, dental prostheses, etc., can solve the problems of difficult to exert the osteogenic effect and can not be distributed evenly for a long time, to inhibit the growth of bacteria and induce osteogenesis. effect, the effect of reducing the inflammatory response

Inactive Publication Date: 2012-02-22
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

BMP degrades rapidly in local tissues or diffuses with body fluids, and cannot be distributed evenly in bone defects for a long time, making it difficult to exert an ideal osteogenic effect
The effect of simply applying exogenous BMP to treat bone defects is not ideal, so it must be compounded with a suitable carrier material to play a role in the sustained release of BMP

Method used

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  • Rare earth element cerium slow-release artificial tooth root based on nanotube array surface
  • Rare earth element cerium slow-release artificial tooth root based on nanotube array surface
  • Rare earth element cerium slow-release artificial tooth root based on nanotube array surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) First choose pure titanium to process the artificial tooth root;

[0030] (2) Surface pretreatment of the artificial tooth root: After the surface is polished, it is washed with acetone, deionized water and absolute ethanol in sequence for 10-30 minutes, followed by HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 20-40 seconds, rinse thoroughly with deionized water, and dry for use;

[0031] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.3wt% (mass percent);

[0032](4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial tooth root is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage ...

Embodiment 2

[0037] (1) First choose titanium to process the artificial tooth root;

[0038] (2) Surface pretreatment of the artificial tooth root: After the surface is polished, it is washed with acetone, deionized water and absolute ethanol in sequence for 30-60 minutes, followed by HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 40-60 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0039] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0040] (4) Preparation of titanium dioxide nanotubes by two-step anodic oxidation: the surface pretreated artificial tooth root is used as the anode, graphite is used as the cathode, and the first anodic oxidation is carried out in an aqueous organic electrolyte solution. The specific anodic oxidation para...

Embodiment 3

[0045] (1) First choose pure titanium to process the artificial tooth root;

[0046] (2) Surface pretreatment of the artificial tooth root: After the surface is polished, it is washed with acetone, deionized water and absolute ethanol in sequence for 60-90 minutes, followed by HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 60-80 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0047] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 4vol% (volume percent), phosphoric acid 6vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0048] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial tooth root is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodizat...

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Abstract

The invention relates to a rare earth element cerium slow-release artificial tooth root based on the nanotube array surface. There is a layer of cerium-doped sodium titanate nanotube array layer with a tubular structure on the surface of the artificial tooth root metal matrix, and further Loaded with bone morphogenetic protein (BMP). The preparation method of the rare earth element cerium sustained-release artificial tooth root based on the nanotube array surface is as follows: select pure titanium or titanium alloy to process the artificial tooth root; then use two-step anodic oxidation technology to obtain a tubular Structured titanium dioxide nanotube array layer; then the titanium dioxide nanotube array layer is converted into a sodium titanate nanotube array layer by lye hydrothermal synthesis technology; and then doped with rare earth in the sodium titanate nanotube array layer element cerium; finally, the bone morphogenetic protein was loaded in the cerium-doped sodium titanate nanotube array layer by centrifugal loading technology.

Description

technical field [0001] The present invention relates to a rare earth element cerium sustained-release artificial tooth root based on a nanotube array surface, in particular to an artificial tooth root with cerium-doped sodium titanate nanotubes loaded with bone morphogenetic protein (BMP) on the surface and a preparation method thereof The invention belongs to the technical field of artificial tooth root materials. Background technique [0002] Dental implants are internationally recognized as the first choice for restoration of missing teeth. They are similar to real teeth in terms of function, shape, and use effects, and can be called "artificial teeth." Dental implants are composed of artificial tooth roots and porcelain crowns. Pure titanium and its alloys are widely used in the manufacture of artificial tooth roots for dental implants. However, ordinary titanium dioxide layers are not active enough to form a direct bond with bone, which sometimes translates into a lack...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/04A61K6/02
Inventor 储成林余青青林萍华
Owner 江苏广达医材集团有限公司
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