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Medicine composition for treating vaginitis as well as gel and preparation method thereof

A vaginitis and gel technology, which is applied in the directions of drug combinations, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc., can solve the problems of insufficient safety of nanomaterials, the generation of drug-resistant vaginal flora, and easy pathogenesis, and it is not easy to achieve. The effect of producing drug resistance, improving sensitivity, and broad antibacterial spectrum

Inactive Publication Date: 2010-06-30
湖南天龙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the defects that existing antibiotics for treating atrophic vaginitis are easy to produce drug-resistant bacteria and cause vaginal flora imbalance, excessive estrogen intake is easy to cause disease, and the safety of nanomaterials is insufficient, and provides a new vaginal treatment method. pharmaceutical composition for inflammation

Method used

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  • Medicine composition for treating vaginitis as well as gel and preparation method thereof
  • Medicine composition for treating vaginitis as well as gel and preparation method thereof
  • Medicine composition for treating vaginitis as well as gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: Preparation of the pharmaceutical composition of the present invention

[0057] A kind of pharmaceutical composition for the treatment of vaginitis, the components are calculated by weight percentage:

[0058] Blueberry Essential Oil 0.1%

[0059] Borneol 20.0%

[0060] Vitamin E 0.5%

[0061] Arginine 0.5%

[0062] Nitroglycerin or pentetrol 1.0%

[0063] The balance is water.

[0064] The blue lotus essential oil is mixed with blue eucalyptus leaves and peppermint leaves at a ratio of 1:1, adding 3-5 times of 80°C hot water for steam distillation, collecting the distillate, adding NaCl salting out, standing still, and separating the upper oil layer to obtain final product; The borneol essence is steam distilled after adding 3-5 times of hot water at 80° C. to leaves of camphor tree, and the distilled liquid is collected, salted out with NaCl, and crystallized after cooling.

Embodiment 2

[0065] Embodiment 2: Preparation of the pharmaceutical composition of the present invention

[0066] A kind of pharmaceutical composition for the treatment of vaginitis, the components are calculated by weight percentage:

[0067] Blueberry Essential Oil 20.0%

[0068] Borneol 0.1%

[0069] Vitamin E 5.0%

[0070] Arginine 15.0%

[0071] Nitroglycerin or pentanitronitrate 0.5%

[0072] The balance is water.

Embodiment 3

[0073] Embodiment 3: prepare the gel of pharmaceutical composition of the present invention

[0074] Its formula is calculated by weight percentage as:

[0075] Blueberry Essential Oil 20.0%

[0076] Borneol 0.1%

[0077] Vitamin E 5.0%

[0078] Arginine 0.5%

[0079] Nitroglycerin or pentetrol 1.0%

[0080] Sorbic acid 0.05%

[0081] Polyacrylic resin 5.0%

[0082] Glycerin 5.00%

[0083] Liquid paraffin 30.0%

[0084] The balance is water.

[0085] The blue lotus essential oil is mixed with blue eucalyptus leaves and peppermint leaves at a ratio of 1:1, adding 3-5 times of 80°C hot water for steam distillation, collecting the distillate, adding NaCl salting out, standing still, and separating the upper oil layer to obtain final product; The borneol essence is steam distilled after adding 3-5 times of hot water at 80° C. to leaves of camphor tree, and the distilled liquid is collected, salted out with NaCl, and crystallized after cooling.

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Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a medicine composition for treating vaginitis, which comprises the following components in percentage by weight: 0.1-20.0 percent of blue lotus essential oil, 0.1-20.0 percent of borneol essence, 0.5-5.0 percent of vitamin E, 0.5-15.0 percent of arginine and 0.5-1.0 percent of nitroglycerin or pentaerythritol tetranitrate. The invention also provides a gel of the medicine composition and a preparation method thereof. The medicine composition and the gel thereof can improve the blood circulation around vagina and prevent premature aging of epithelial cells of the vagina, and have no side effect and potential risk on human bodies after long-time use. In the invention, antibiosis experiments show that the medicine composition can inhibit the growth of various pathogenic bacteria, acute skin irritancy tests show that no toxic reaction is found, the microbiological indices of the medicine composition reach the standard, and no pathogenic bacteria exists, thereby the invention has a wide application prospect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating vaginitis, a gel and a preparation method thereof. Background technique [0002] Vaginitis is a common disease in gynecology, especially the incidence rate of atrophic vaginitis is as high as 40-60%, which has a great impact on women's work and life. Atrophic vaginitis is an inflammation caused by ovarian function decline, estrogen level reduction, vaginal wall atrophy, mucous membrane thinning, glycogen content in epithelial cells decreases, intravaginal PH value increases, local resistance decreases, and pathogenic bacteria invade and multiply . [0003] Clinically, the treatment of atrophic vaginitis is mainly the application of estrogen and antibiotics for symptomatic treatment of vaginal dryness symptoms. For example, the Chinese patent application number 89105335.2 discloses formulas of glycerin, honey, and liquid paraf...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61P15/02A61P9/00A61K31/045A61K31/355A61K31/198A61K31/21
Inventor 柯缨
Owner 湖南天龙制药有限公司
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