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Application of forsythiaside A in preparing hepatitis B therapeutic drug

A technology of forsythiaside and hepatitis B, applied in the field of medicine, can solve the problem that the antiviral pharmacological activity of forsythiaside A is few and other problems

Active Publication Date: 2010-06-30
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few studies on the antiviral pharmacological activity of forsythiaside A in the prior art

Method used

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  • Application of forsythiaside A in preparing hepatitis B therapeutic drug

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1 (forsythiaside A anti-hepatitis B virus test in vitro)

[0011] 1. Purpose of the test:

[0012] To observe the pharmacodynamic effect of forsythiaside A against hepatitis B virus.

[0013] 2. Test materials:

[0014] Test drug: Forsythiaside A freeze-dried powder injection, provided by Shanghai Yusen New Drug Development Co., Ltd., batch number: 060909.

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Abstract

The invention discloses an application of forsythiaside A in preparing a hepatitis B therapeutic drug. An anti-hepatitis B virus test in vitro of the forsythiaside A shows that the forsythiaside A can effectively inhibit hepatitis B antigen and hepatitis B viruses, which is characterized by the following aspects: using a HepG2.2.2.15 cell model, TC50 cytotoxicity of the forsythiaside A in vitro is equal to 739mu g / mL; IC50 of inhabitation on S antigen is equal to 149.4mu g / mL; IC50 of inhabitation on e antigen is equal to 139.6mu g / mL; and IC50 of inhabitation on a cell HBV-DNA is equal to 56.3mu g / mL.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new medicine application of forsythiaside A. Background technique [0002] Forsythoside A (Forsythoside A) is an active ingredient extracted from the plant Forsythia (Fructus Forsythiae) of Oleaceae. In the past, forsythiaside was used as an index to investigate the extraction process of forsythia. In recent years, with the deepening of research on the active ingredients of forsythia, it was found that forsythin has no antibacterial activity, and forsythiaside A has the antibacterial activity. Its structural formula is as follows: [0003] [0004] In recent years, it has been reported in the literature that forsythiaside has a good antibacterial effect: For example, Wang Hongjun et al. reported that forsythiaside has antibacterial effects on Staphylococcus aureus, Streptococcus dysgalactia, and nongalactiae in vitro and in vivo that cause mastitis in dairy cows...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61P1/16A61P31/12
CPCA61K31/7028A61P1/16A61P31/12A61P31/20
Inventor 玄振玉
Owner SHANDONG NEWTIME PHARMA
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