Metformin-glibenclamide capsule and preparation method thereof

Abstract

The invention discloses a metformin-glibenclamide capsule, which is prepared by the following steps: super-finely crushing 250 parts of metformin hydrochloride by weight and 1.25 parts of glibenclamide by weight or 250 parts of the metformin hydrochloride by weight and 2.5 parts of the glibenclamide by weight into superfine powder of 1-100 microns, adding 3-30 parts of disintegrant by weight and 0.15-2 parts of lubricating agent by weight, uniformly mixing, putting into a novel powder feeder and finally filling by using a novel capsule filler. Compared with the prior art, the metformin-glibenclamide capsule prepared by the invention has small weight difference, uniform content, excellent dissolution and stable quality.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a metformin glibenclamide capsule and a preparation method thereof. Background technique [0002] Diabetes is the second disease after cardiovascular disease. According to WHO survey results, there are hundreds of millions of diabetics in the world, and more than 90% of them are type II diabetics. According to the results of epidemiological survey in my country, in the general population, the proportion of patients with type II diabetes is 1-2%, and the proportion of people over 50 years old is as high as 10%. There are more than 30 million patients diagnosed with type II diabetes in my country. people. With the improvement of people's living standards, the prevalence of diabetes has been increasing rapidly in recent years, especially obese patients with type II diabetes have increased significantly, and these patients have poor sensitivity to insulin, which has always ...

AI Technical Summary

Problems solved by technology

[0012] Although metformin glibenclamide oral preparations have been disclosed in the prior art, such as metformin glibenclamide tablets, metformin glibenclamide capsules, etc., the production of existing capsules is due to the limitations of conditions such as technology, equipment, etc. Make the weight difference, content uniformity, dissolution rate of capsule difficult to control, and stability is relatively poor, the metformin glibenclamide capsule produced by improving process technology and equipment disclosed in literature has not yet been seen, especially weight difference, content uniformity can be achieved. Metformin glibenclamide capsules with excellent dissolution performance and stable quality

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