Process for enriching total alkaloids of sessile stemona root

Abstract

The invention belongs to the field of medicaments and in particular relates to a process for enriching total alkaloids of sessile stemona root. The process is an extraction and purification process of membrane separation and macroporous resin coupling technology, obviously improves the separation and purification efficiency of macroporous resin on main medicinal active components, prolongs the service life of the macroporous resin, improves the yield and the quality of products, and remarkably reduces the preparation cost of the products; the membrane separation and macroporous resin coupling technology can effectively remove proteins, polysaccharide and other macromolecular impurity compositions in crude extract of the sessile stemona root, and obviously improves the purity and the quality of the total alkaloids of the extract of the sessile stemona root; other toxic organic solvents except ethanol are not used in the whole extraction and separation process, the membrane separation efficiency is good, the process is performed at low temperature, the antipollution is strong, the regeneration and cleaning are easy, the process is favorable for a subsequent process for further purification by adopting the macroporous resin, the macroporous resin can be repeatedly used, the industrialized production is safe and the cost is low; and the prepared alkaloid of the sessile stemona root has high purity.

Description

Technical field: [0001] The invention belongs to the field of medicine, and in particular relates to a process for enriching total alkaloids Background technique: [0002] Baibu is a commonly used traditional Chinese medicine, which was first recorded in "Bielu of Famous Doctors" and listed as a Chinese medicine. "Temperature, slightly poisonous, mainly used for cough and shortness of breath." It has been recorded in medical literature of all dynasties since then, and it is mostly used as a lice and cough medicine. For example, in "Compendium of Materia Medica", "Hundred Bubbles" are the sages who said that they can cure chronic cough, and what the nunnery said is that they can cure chronic cough and protect the lungs. "Insecticide." "New Compilation of Materia Medica" "Hundreds, kills insects without consuming energy and blood. It is most beneficial to people, but its power is very small, so you might as well use more. However, it is better to use it with ginseng, poria, ...

AI Technical Summary

Problems solved by technology

[0003] After reviewing the domestic and foreign literature reports on Ceprea, it is found that there are few extraction methods for the total alkaloids of Ceprea, all of which use alcohol extraction and then extraction with organic solvents such as chloroform. The extraction rate is low, the safety is small, and it is not conducive to large-scale production.

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