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Hollow fiber ultrafiltration composite membrane, preparation method and application thereof

A technology of ultrafiltration composite membrane and hollow fiber, which is applied in the direction of chemical instruments and methods, membrane technology, semipermeable membrane separation, etc., can solve the problems of increasing activation degree and affecting the biocompatibility of polysulfone membrane materials, and achieve reduction Stimulation, improved blood compatibility, low complement activating factor effects

Inactive Publication Date: 2010-05-12
江苏朗生生命科技有限公司
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Problems solved by technology

As disclosed in CN1158273A "polysulfone hollow fiber semi-permeable membrane", adding polyvinylpyrrolidone (PVP) will increase the membrane's complement activating factor in blood, but the degree of activation will increase with the increase of PVP content, thereby affecting polysulfone Inherent biocompatibility of membrane materials

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  • Hollow fiber ultrafiltration composite membrane, preparation method and application thereof
  • Hollow fiber ultrafiltration composite membrane, preparation method and application thereof
  • Hollow fiber ultrafiltration composite membrane, preparation method and application thereof

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Embodiment Construction

[0017] The hollow fiber ultrafiltration composite membrane of the present invention, its raw material is made up of the component that has following percentage by weight, the membrane material of 15-25%, the porogen of 5-15%, the organic solvent of 55-75% and 5-10% % lithium chloride, and the membrane material is a mixture of one of polysulfone, polyethersulfone, polyacrylonitrile, polymethyl methacrylate or cellulose triacetate and 1-5% chitosan. The chitosan viscosity average molecular weight of the present invention is 300000-1000000, and the chitosan viscosity average molecular weight is preferably controlled between 500000-800000, and the chitosan N-deacetylation degree is 60%~100%. The organic solvent of the present invention It is one of N-methyl-2-pyrrolidone, dimethylacetamide or dimethyl sulfoxide, and the porogen is one of polyvinylpyrrolidone, polyethylene glycol and polyvinyl alcohol or a mixture of any two of them , above-mentioned each raw material is commercial...

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Abstract

The invention relates to a hollow fiber ultrafiltration composite membrane composed of the components in the following weight percent: 15-25% of membrane material, 5-15% of pore-making agent, 55-75% of organic solvent and 5-10% of lithium chloride; the membrane material is a mixture of chitosan and one of polysulfone, polyether sulfone, polyacrylonitrile, polymethyl methacrylate, or cellulose triacetate, wherein the chitosan accounts for 1-5% of the total weight of the raw material, and the average molecular weight of chitosan ranges from 300,000 to 1,000,000; the pore-making agent is one of polyvinylpyrrolidone, polyethyleneglycol, or polyvinyl alcohol, or a mixture thereof; and the organic solvent is one of N-methyl-2-pyrrolidone, dimethyl fomamide, dimethyl acetamide, or dimethyl sulfoxide. The invention has good bioactivity, biocompatibility, anti-coagulation property and other properties.

Description

technical field [0001] The invention relates to a hollow fiber ultrafiltration membrane, a preparation method and trial application thereof, and belongs to the technical field of hollow fiber membranes used in hemodialyzers and hemofilters. Background technique [0002] At present, there are many kinds of hollow fiber membranes used in hemodialyzers and hemohemofilters. Polysulfone dialysis membranes have good biocompatibility, excellent mechanical properties, high solute permeability, and high removal rate of middle molecular toxins. With less blood volume and low price, it is one of the most commonly used membrane materials at present. However, since polysulfone, polyethersulfone, polyacrylonitrile and other artificially synthesized membrane materials are strongly hydrophobic materials, in order to improve the hydrophilic performance of polysulfone membranes, polyvinylpyrrolidone (PVP) and polyvinyl alcohol are mainly used at home and abroad. (PVA), polyethylene glycol (P...

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Application Information

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IPC IPC(8): B01D69/12B01D71/74A61M1/14
Inventor 戈旭亚唐勇红
Owner 江苏朗生生命科技有限公司
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