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Application of notoginseng and extract thereof in preparing medicaments for treating and/or preventing coronary artherosclerosis

A technology of coronary atherosclerosis and plant extracts, which is applied in the field of preparation of drugs for the treatment and/or prevention of coronary atherosclerosis, can solve the problems of complex ingredients, lack of mechanism of action of ingredients, and research, so as to prevent the recurrence of thrombus, Improve microcirculation and reduce the effect of generation

Active Publication Date: 2010-04-28
许淑清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of the ingredients in the total saponins of Panax notoginseng, it is not yet clear which ingredients play the main therapeutic role, and no one has done a comprehensive study on the mechanism of action between the ingredients.

Method used

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  • Application of notoginseng and extract thereof in preparing medicaments for treating and/or preventing coronary artherosclerosis
  • Application of notoginseng and extract thereof in preparing medicaments for treating and/or preventing coronary artherosclerosis
  • Application of notoginseng and extract thereof in preparing medicaments for treating and/or preventing coronary artherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0230] Take notoginseng and grind it into 1000g of coarse powder, add 7000ml of 65% ethanol to extract for 7 hours, collect the extract, filter, take the filtrate to recover the ethanol until it has no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, gradient elution with different concentrations of ethanol, the ethanol concentration is adjusted from 5% to 95% within 6 hours , flow rate 4.5BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and concentrate To a clear paste with a relative density of 1.13 (60° C.), the active ingredient of Panax notoginseng saponins is obtained, and water for injection is added to adjust to contain 100 m...

Embodiment 2

[0233] Take notoginseng and grind it into 1000g of coarse powder, add 10000ml of 50% ethanol to extract for 6 hours, collect the extract, filter, take the filtrate to recover the ethanol until it has no alcohol smell, add water to make a solution containing 0.4g of crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, carry out gradient elution with different concentrations of ethanol (the ethanol concentration is adjusted from 5% to 95% within 5.5 hours ), the flow rate is 5.0BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and Concentrate to a clear paste with a relative density of 1.15 (60°C), dry it to obtain the active ingredient of Panax notoginseng saponins, add water for injection to adjust t...

Embodiment 3

[0236]Take notoginseng and grind it into coarse powder 1000g, add 75% ethanol 7500ml to extract for 8 hours, collect the extract, filter, take the filtrate to recover ethanol until it has no alcohol smell, add water to make a solution containing 0.6g crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, carry out gradient elution with different concentrations of ethanol (the ethanol concentration is adjusted from 5% to 95% within 6.5 hours ), the flow rate is 4.0BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and Concentrate to a clear paste with a relative density of 1.16 (60°C) to obtain the active ingredient of Panax notoginseng saponins, add 0.30% (weight ratio) of activated carbon for injection...

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Abstract

The invention relates to novel application of notoginseng, notoginseng extract, panax notoginseng saponins and a panax notoginseng saponins composition, namely, novel application in preparing medicaments for treating and / or preventing coronary artherosclerosis.

Description

technical field [0001] The invention relates to the new application of notoginseng, notoginseng extract, total notoginseng saponins and the composition of notoginseng total saponins, especially the new application in preparing medicines for treating and / or preventing coronary atherosclerosis. Background technique [0002] In recent years, with the development of my country's economy, the morbidity and mortality of cardiovascular and cerebrovascular diseases have increased year by year, and it has been called the number one killer that endangers human health and life. Coronary atherosclerosis (collectively referred to as coronary heart disease, referred to as coronary heart disease) is the most common and most important of a group of arteriosclerotic vascular diseases, which is characterized by the involvement of arterial lesions starting from the intima. Generally, there is accumulation of lipids and complex carbohydrates, hemorrhage and thrombosis, fibrous tissue hyperplasi...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P9/10A61K31/704
Inventor 许淑清赵学伟陈明
Owner 许淑清
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