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Method for preparing medical nanoparticles

A nanoparticle and quantum dot technology, which is applied in the field of preparing medical bifunctional nanoparticles, can solve the problems of complex process, difficult purification, unfavorable application, etc., and achieve the effect of improving stability and excellent fluorescent properties

Inactive Publication Date: 2010-04-21
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the particle size of the quantum dots coated by this method is relatively large, which is not conducive to the application in biology.
(4) Encapsulation is achieved through the hydrophobic interaction between the amphiphilic polymer and the alkyl chain on the surface of the quantum dot. Since this method does not destroy the organic molecules on the surface of the quantum dot, its optical properties are basically not affected, but a large amount of organic solvent is used. , the process is complex and difficult to purify

Method used

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Examples

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Embodiment 1

[0031] Example 1: Synthesis of polyamide-amine dendrimers (PAMAM) 1

[0032] The synthesis of polyamide-amine (PAMAM) dendrimers adopts the divergent method, that is, the molecules grow outward from the core. According to the law of tree branching, the pre-prepared monomers are combined in sequence according to the order of the radial shape, the branches of the branches, and then branches. Using ethylenediamine as the starting material, the 0.5-generation dendritic polyamide-amine (PAMAM) molecule was obtained through the Michael addition reaction with excess methyl methacrylate in methanol, and then the 0.5-generation dendritic Polyamidoamine (PAMAM) undergoes ammonolysis reaction with excess ethylenediamine to obtain dendritic polyamidoamine (PAMAM) of generation 1. Repeat the above two steps to obtain dendrimers with higher generations.

Embodiment 2

[0033] Embodiment 2: Synthesis 2 of polyamide-amine type dendrimers (PAMAM)

[0034] The synthesis of dendrimer polyamide-amine (PAMAM) adopts the convergent method, that is, the synthetic strategy of linking the pre-synthesized dendritic oligomers to the core molecule sequentially. This method is just the opposite of the divergence method mentioned above. The synthesis step is to first synthesize small branches one by one, and then these small branches are connected in pairs to develop into larger "branches". Finally, two (or more) Large, symmetrical "branches" join together to form dendrimers.

Embodiment 3

[0035] Embodiment 3: Modified polyamide-amine (PAMAM-PEG-NH2) 1 with polyethylene glycol

[0036] 2.5 generations of dendritic polyamidoamines (PAMAM) are dissolved in methanol, and under ice-salt bath conditions, the molar ratio of polyamidoamines (PAMAM) and polyethylene glycol (PEG) with amino groups on both sides is 1 : 1, polyamide-amine (PAMAM) was added dropwise in polyethylene glycol (NH2-PEG-NH2), after the dropwise addition was completed, the ice-salt bath was removed, and after reacting at room temperature for 2 hours, dialyzed and rotary evaporated to obtain The product polyamidoamine-polyethylene glycol; (PAMAM-PEG-NH2).

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Abstract

The invention relates to a method for preparing medical nanoparticles and belongs to the technical field of nano material preparation. The method comprises the following steps: modifying poly(amidoamine) by polyethylene glycol; modifying folic acid on the polyethylene glycol; coating quantum dots by the poly(amidoamine) modified by the polyethylene glycol and the folic acid; clamping anti-cancer medicaments into poly(amidoamine) or connecting the medicaments to the surface of the poly(amidoamine); using oil-soluble quantum dots coated by the poly(amidoamine) as nano ligands of nuclear shell structures; modifying the folic acid and polyethylene glycol on the surface of the poly(amidoamine); and positioning the poly(amidoamine) onto the surfaces of tumor cells by using the special affinity between folic acid receptors on the surface of the tumor cells and the folic acid. Meanwhile, due to the special structural characteristics of PAMAM, the internal cavities of the poly(amidoamine) can hold the anti-cancer medicaments or the surface of the poly(amidoamine) can be connected with the anti-cancer medicaments, so the toxic and side effects of the medicaments on normal tissues are reduced greatly and the stability and water solubility of the quantum dots are improved.

Description

technical field [0001] The invention relates to the field of preparation of nanomaterials, in particular to a method for preparing medical bifunctional nanoparticles. Background technique [0002] Polyamidoamine (PAMAM) dendrimers exhibit exceptional properties due to their unique molecular structures, and initial research has focused on their synthesis. Research interest has now turned to performance and applications. For example, there are many new applications in catalysis, medical treatment, microelectronics, liquid crystal materials, and new nanomaterials. At present, the application potential of dendrimers has been extensively studied abroad, among which the research in the medical field mainly focuses on gene carriers, drug carriers, magnetic resonance contrast agents and boron neutron capture therapy reagents. The novel structure of dendrimers can be used as a multifunctional platform for internal-external receptor-substrate (host-guest) interactions. It can be us...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/48A61K47/34A61K47/22A61K45/00A61K31/337A61K31/704A61K31/519A61K49/00A61P35/00A61K47/10A61K47/59A61K47/60
Inventor 李亚鹏赵义丽王静媛
Owner JILIN UNIV
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